Objective: Our aim was to compare the effect of lacidipine and chlorthalidone on
cardiovascular outcome as a primary parameter and blood pressure as a secondary in …

This randomised, double-blind, double-dummy, parallel group, multicentre study compared
the efficacy and tolerability of lercanidipine with lacidipine. Elderly patients with isolated …

Aims: Isolated systolic hypertension affects over 8 to 15% of all subjects older than 60 years.
In the elderly, systolic hypertension is the major modifiable cardiovascular risk factor. Three …

Abstract The Systolic Hypertension in the Elderly Program (SHEP) is a randomized, blinded
test of the efficacy of antihypertensive drug treatment. In a large feasibility trial, 551 men and …

One hundred seventy‐one patients, 60 years of age or older with isolated systolic
hypertension, were randomly assigned to receive chlorthalidone 12.5, 25.0, or 50.0 mg or …

The Syst-Eur study investigated whether active antihypertensive treatment could reduce
cardiovascular complications in elderly patients with isolated systolic hypertension …

SHEP-Pilot Study, a randomized, double-blind, placebo-controlled trial of drug therapy for
isolated systolic hypertension, followed 551 participants aged 60 years or more with …

In the early stage of hypertension, diastolic blood pressure has greater prognostic
importance, but in the elderly, systolic blood pressure is the most important marker of …

Background and objective This interim report from the Syst-Eur trial investigated the level of
blood pressure control achieved during the double-blind period in patients followed in …

The pharmacological treatment, mainly based on diuretics, of isolated systolic hypertension
(ISH) has recently been shown to reduce the risk of stroke and coronary heart disease in the …