Shikonin induces apoptosis, necrosis, and premature senescence of human A549 lung cancer cells through upregulation of p53 expression
YC Yeh, TJ Liu, HC Lai - Evidence‐based Complementary and …, 2015 - Wiley Online Library
Shikonin, a natural naphthoquinone pigment isolated from Lithospermum erythrorhizon, has
been reported to suppress growth of various cancer cells. This study was aimed to …
been reported to suppress growth of various cancer cells. This study was aimed to …
Shikonin causes cell-cycle arrest and induces apoptosis by regulating the EGFR–NF-κB signalling pathway in human epidermoid carcinoma A431 cells
R Tian, Y Li, M Gao - Bioscience reports, 2015 - portlandpress.com
Shikonin, a naphthoquinone pigment isolated from the Chinese herbal Zicao, has been
shown to exhibit antioxidant and anticancer effects. In the present study, we investigated the …
shown to exhibit antioxidant and anticancer effects. In the present study, we investigated the …
[HTML][HTML] Shikonin induces apoptotic cell death via regulation of p53 and Nrf2 in AGS human stomach carcinoma cells
H Ko, SJ Kim, SH Shim, HI Chang… - Biomolecules & …, 2016 - ncbi.nlm.nih.gov
Shikonin, which derives from Lithospermum erythrorhizon, has been traditionally used
against a variety of diseases, including cancer, in Eastern Asia. Here we determined that …
against a variety of diseases, including cancer, in Eastern Asia. Here we determined that …
Shikonin inhibits cancer through P21 upregulation and apoptosis induction
F Wang, F Mayca Pozo, D Tian, X Geng… - Frontiers in …, 2020 - frontiersin.org
Shikonin is a natural naphthoquinone compound and has demonstrated potent anti-cancer
activities; however, the underlying molecular mechanisms remained elusive. Here we report …
activities; however, the underlying molecular mechanisms remained elusive. Here we report …
Shikonin inhibits proliferation of melanoma cells by MAPK pathway-mediated induction of apoptosis
JH Lee, SH Han, YM Kim, SH Kim, ES Yoo… - Bioscience …, 2021 - portlandpress.com
Shikonin, a natural product isolated from the roots of Lithospermum erythrorhizon, exhibits
pharmacological effects against inflammation, ulcers, infections, and tumors. In the present …
pharmacological effects against inflammation, ulcers, infections, and tumors. In the present …
Up-regulation of p53/miR-628-3p pathway, a novel mechanism of shikonin on inhibiting proliferation and inducing apoptosis of A549 and PC-9 non–small cell lung …
J Pan, M Li, F Yu, F Zhu, L Wang, D Ning… - Frontiers in …, 2021 - frontiersin.org
Shikonin (SHK) is a pleiotropic agent with remarkable cell growth inhibition activity against
various cancer types, especially non–small cell lung cancer (NSCLC), but its molecular …
various cancer types, especially non–small cell lung cancer (NSCLC), but its molecular …
Mechanisms behind the inhibition of lung adenocarcinoma cell by shikonin
W Lan, S Wan, W Gu, H Wang, S Zhou - Cell biochemistry and biophysics, 2014 - Springer
Shikonin, a natural naphthoquinone isolated from a traditional Chinese medicinal herb, can
exert inhibitory effect on tumor cell growth. However, little has been known concerning the …
exert inhibitory effect on tumor cell growth. However, little has been known concerning the …
p53-mediated cell cycle arrest and apoptosis induced by shikonin via a caspase-9-dependent mechanism in human malignant melanoma A375-S2 cells
Z Wu, L Wu, L Li, S Tashiro, S Onodera… - Journal of …, 2004 - Elsevier
Natural products regulate cell growth in response to oncogene activation that induces cell
cycle arrest and apoptosis in tumor cell lines. We investigated the mechanisms of caspase …
cycle arrest and apoptosis in tumor cell lines. We investigated the mechanisms of caspase …
Uncovering the antitumor effects and mechanisms of Shikonin against colon cancer on comprehensive analysis
Y Chen, L Si, J Zhang, H Yu, X Liu, Y Chen, Y Wu - Phytomedicine, 2021 - Elsevier
Background Shikonin, a naphthoquinone compound extracted from the root of
Lithospermum erythrorhizon, has been extensively studied for its antitumor activity …
Lithospermum erythrorhizon, has been extensively studied for its antitumor activity …
Anti-tumor activity of Shikonin against afatinib resistant non-small cell lung cancer via negative regulation of PI3K/Akt signaling pathway
B Li, Z Yuan, J Jiang, Y Rao - Bioscience reports, 2018 - portlandpress.com
Acquired resistance of afatinib is a significant challenge for non-small cell lung cancer
(NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal …
(NSCLC) therapy and the mechanisms remain unclear. Aberrant activation of epidermal …