Apoptosis is a process that leads to programmed cell death and also a therapeutic target of
cancer. In this study, potential apoptotic effects of shikonin on human bladder cancer cells …

Phytochemicals gained considerable interest during the past years as source to develop
new treatment options for chemoprevention and cancer therapy. Motivated by the fact that a …

Non-small cell lung cancer (NSCLC) is the dominant type of lung cancer. Molecular
targeting has highly improved the treatment efficacy of lung cancer, but new challenges …

Acetylshikonin, a natural naphthoquinone derivative compound from Lithospermum
erythrorhyzon, has been reported to kill bacteria, suppress inflammation, and inhibit tumor …

In this study, a series of novel shikonin derivatives (30–49) were designed and synthesized
and their anti-proliferative activities were evaluated against five different cancer cell lines …

Breast cancer is the most common malignancy in women. Apoptosis is important for tumor
suppression and may delay cancer progression. It was found that shikonin induced …

Shikonin, which is a major ingredient of the traditional Chinese herb Lithospermum
erythrorhizon, possesses various biological functions, including antimicrobial, anti …

Liquiritin, isoliquiritin and isoliquirigenin are the active polyphenols present in Glycyrrhiza
uralensis which has been used for the treatment of cancer and its complications. The …

Increasing evidences indicate that shikonin can suppress the tumor growth. However, the
mechanisms remain elusive. In the present study, we investigated the effects and …

Acute promyelocytic leukemia (APL) is a special subtype of acute myeloid leukemia that
responds to treatment with all‑trans retinoic acid and arsenic trioxide. However, severe side …