Diverse oxidative pathways, such as direct oxidation of amino acids, glycoxidation, and
lipoxidation could contribute to Alzheimer disease pathogenesis. A global survey for the …

Oxidative alterations of proteins by reactive oxygen species (ROS) have been implicated in
the progression of aging and age-related neurodegenerative disorders such as Alzheimer's …

Numerous studies have shown that neuronal lipids are highly susceptible to oxidative stress
including in those brain areas directly involved in the neurodegenerative process of …

Alzheimer's disease (AD) is an age-related neurodegenerative disorder. A number of
hypotheses have been proposed to explain AD pathogenesis. One such hypothesis …

Oxidative stress is a key factor involved in the development and progression of Alzheimer
disease (AD), and it is well documented that free radical oxidative damage, particularly of …

In this study we used immunohistochemistry and two-dimensional fingerprinting of
oxidatively modified proteins (two-dimensional Oxyblot) together to investigate protein …

抄録 There has been much evidence demonstrating the involvement of oxidative stress in
the pathology of neurological disorders. Moreover, the vulnerability of the central nervous …

Cytoskeletal disruption is one of the distinguishing characteristics of the vulnerable neurons
in Alzheimer disease (AD). It has been suggested that these cytoskeletal changes occur …

Amyloid β-peptide (Aβ) is heavily deposited in the brains of Alzheimer's disease (AD)
patients. Free-radical oxidative stress, particularly of neuronal lipids, proteins and DNA, is …

Alzheimer's disease (AD), the leading cause of dementia, involves regionalized neuronal
death, synaptic loss, and an accumulation of intraneuronal, neurofibrillary tangles and …