Hypoxia is a pervasive microenvironmental factor that affects normal development as well as
tumor progression. In most normal cells, hypoxia stabilizes hypoxia-inducible transcription …

Hypoxic regions within solid tumors harbor cells that are resistant to standard chemotherapy
and radiotherapy. Because oxygen is required to produce ATP by oxidative phosphorylation …

Cancer cells are characterized by high metabolic demand. The substrates in demand
include oxygen, glucose, glutamine and lipids. Oxygen serves as a key substrate in cellular …

Objectives: The aim of this study is to explore the possible role of HIF-1alpha in glucose
metabolism, proliferation and apoptosis of pancreatic cancerous cells. Method: The …

Tumor tissue oxygenation impacts on proliferation of cancer cells and their sensitivity
towards radio-and chemotherapy. Under low oxygen, mammalian cells show an adaptive …

Hypoxic tumor microenvironment (HTM) is considered to promote metabolic changes,
oncogene activation and epithelial mesenchymal transition, and resistance to chemo-and …

Metabolic reprogramming and altered bioenergetics have emerged as hallmarks of cancer
and an area of active basic and translational cancer research. Drastically upregulated …

Cancer cells have been shown to have altered metabolism when compared to normal non-
malignant cells. The Warburg effect describes a phenomenon in which cancer cells …

The biochemistry of cancer cells diverges significantly from normal cells as a result of a
comprehensive reprogramming of metabolic pathways. A major factor influencing cancer …

Simple Summary This comprehensive review discusses the anticancer effects of plant
phenolic compounds, known as flavonoids, through the targeting of HIF-1 and critical …