Both p150 and p110 isoforms of ADAR1 convert adenosine to inosine in double-stranded
RNA (dsRNA). ADAR1p150 suppresses the dsRNA-sensing mechanism that activates …

Stress granules (SGs) are cytoplasmic assemblies of RNA and protein that form when
translation is repressed during the integrated stress response. SGs assemble from the …

Systematic exploration of cancer cell vulnerabilities can inform the development of novel
cancer therapeutics. Here, through analysis of genome-scale loss-of-function datasets, we …

Adenosine-to-inosine (A-to-I) RNA editing is a post-transcriptional process that amplifies the
repertoire of protein production. Recently, the induction of this process through up-regulation …

Adenosine deaminases acting on RNA (ADARs) are the primary factors underlying
adenosine to inosine (A-to-I) editing in metazoans. Here we report the first global study of …

One type of RNA editing involves the conversion of adenosine residues into inosine in
double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR) …

Adenosine-to-inosine RNA editing constitutes a crucial component of the cellular
transcriptome and critically underpins organism survival and development. While recent …

Adenosine deaminases acting on RNA (ADARs) are editing enzymes that convert
adenosine to inosine in duplex RNA, a modification reaction with wide-ranging …

Type I interferon (IFN) is produced when host sensors detect foreign nucleic acids, but how
sensors differentiate self from nonself nucleic acids, such as double-stranded RNA (dsRNA) …

Adenosine deaminases acting on RNA (ADARs) catalyze the editing of adenosine residues
to inosine (A-to-I) within RNA sequences, mostly in the introns and UTRs (un-translated …