Manipulation of the endocannabinoid system by a general anaesthetic

V Di Marzo - British journal of pharmacology, 2003 - Wiley Online Library
An article appearing in this issue of the British Journal of Pharmacology shows for the first
time that the general anaesthetic propofol inhibits one of the enzymes catalysing …

The general anesthetic propofol increases brain N‐arachidonylethanolamine (anandamide) content and inhibits fatty acid amide hydrolase

S Patel, ER Wohlfeil, DJ Rademacher… - British journal of …, 2003 - Wiley Online Library
Propofol (2, 6‐diisopropylphenol) is widely used as a general anesthetic and for the
maintenance of long‐term sedation. We have tested the hypothesis that propofol alters …

Changes of blood endocannabinoids during anaesthesia: a special case for fatty acid amide hydrolase inhibition by propofol?

C Jarzimski, M Karst, AA Zoerner… - British journal of …, 2012 - Wiley Online Library
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Available data from animal studies
suggest that the narcotic drug propofol interacts with the endocannabinoid system. Inhibition …

Endocannabinoids in the central nervous system-an overview

E Fride - Prostaglandins, Leukotrienes and Essential Fatty Acids …, 2002 - Elsevier
Many aspects of the physiology and pharmacology of anandamide (arachidonoyl ethanol
amide), the first endogenous cannabinoid ligand ('endocannabinoid') isolated from pig …

Effects of general anesthesia on anandamide blood levels in humans

G Schelling, D Hauer, SC Azad… - The Journal of the …, 2006 - pubs.asahq.org
Background The endocannabinoid system includes G-protein-coupled cannabinoid
receptors, the endocannabinoids N-arachidonoylethanolamine (anandamide) and 2 …

Oleamide: a member of the endocannabinoid family?

CJ Fowler - British journal of pharmacology, 2004 - Wiley Online Library
The fatty acid amide class of compounds, which include the endocannabinoid anandamide
and the sleep‐inducing compound oleamide, have been shown in vitro to have a multiplicity …

Why endocannabinoids are not all alike

V Di Marzo, L Cristino - Nature neuroscience, 2008 - nature.com
Why endocannabinoids are not all alike | Nature Neuroscience Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

Regulation of Endocannabinoid Levels under Physiological and Pathological Conditions. A Mini‐review

V DI MARZO - Pharmacy and Pharmacology Communications, 2000 - Wiley Online Library
After the discovery of the endogenous ligands of cannabinoid receptors, the
“endocannabinoids” anandamide (N‐arachidonoyl‐ethanolamine) and 2 …

Biosynthesis and inactivation of endocannabinoids: relevance to their proposed role as neuromodulators

V Di Marzo - Life sciences, 1999 - Elsevier
The two putative endogenous ligands of cannabinoid receptors, anandamide and 2-
arachidonoylglycerol, are synthesized by and released from neurons in a Ca2+-dependent …

New advances in the identification and physiological roles of the components of the endogenous cannabinoid system

E Fride, R Mechoulam - Molecular biology of drug addiction, 2003 - Springer
Many aspects of the physiology and pharmacology of anandamide (arachidonoyl
ethanolamide), the first endogenous cannabinoid ligand (“endocannabinoid”) isolated from …