Tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) is one of the most important
infectious diseases globally. Immune effector mechanisms that lead to protection or …

Induction of Th1 (cell-mediated) immunity and associated production of IFN-γ by CD4+ T
cells has been widely used as a marker of protective immunity against tuberculosis (TB) …

Despite co-evolving with humans for centuries and being intensely studied for decades, the
immune correlates of protection against Mycobacterium tuberculosis (Mtb) have yet to be …

Better understanding of the immunological components and their interactions necessary to
prevent or control Mycobacterium tuberculosis (Mtb) infection in humans is critical for …

There is an urgent need for new and better vaccines against tuberculosis (TB). Current
vaccine design strategies are generally focused on the enhancement of cell-mediated …

It is clear that resistance against acute tuberculosis (TB) is dependent on the host's ability to
generate Th1 immunity. Nevertheless, the role of host immunity in latent TB remains …

Tuberculosis is a significant health problem without an effective vaccine to combat it. A
thorough understanding of the immune response and correlates of protection is needed to …

Tuberculosis (TB) remains a serious global public health problem that results in up to 2
million deaths each year. TB is caused by the human pathogen, Mycobacterium tuberculosis …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), remains a major
worldwide health problem that causes more than 2 million deaths annually. In addition, an …

Tuberculosis infects one quarter of the world's population and is the leading cause of death
by a single infectious agent, responsible for a reported 1.3 million deaths in 2017. While …