The endothelium is both a target and a barrier of HDL's protective functions

J Robert, E Osto, A von Eckardstein - Cells, 2021 - mdpi.com
The vascular endothelium serves as a barrier between the intravascular and extravascular
compartments. High-density lipoproteins (HDL) have two kinds of interactions with this …

HDL and endothelial protection

A Tran‐Dinh, D Diallo, S Delbosc… - British journal of …, 2013 - Wiley Online Library
High‐density lipoproteins (HDLs) represent a family of particles characterized by the
presence of apolipoprotein A‐I (apo A‐I) and by their ability to transport cholesterol from …

The protein cargo of HDL: implications for vascular wall biology and therapeutics

JW Heinecke - Journal of clinical lipidology, 2010 - Elsevier
High-density lipoprotein (HDL) is proposed to inhibit atherosclerosis via a number of
different pathways, including promotion of reverse cholesterol transport and inhibition of …

Novel biological functions of high-density lipoprotein cholesterol

C Mineo, PW Shaul - Circulation research, 2012 - Am Heart Assoc
In addition to its role in reverse cholesterol transport, high-density lipoprotein (HDL)
cholesterol has direct action on numerous cell types that influence cardiovascular and …

Cholesterol efflux and atheroprotection: advancing the concept of reverse cholesterol transport

RS Rosenson, HB Brewer Jr, WS Davidson, ZA Fayad… - Circulation, 2012 - Am Heart Assoc
High-density lipoprotein (HDL) has been proposed to have several antiatherosclerotic
properties, including the ability to mediate macrophage cholesterol efflux, antioxidant …

[PDF][PDF] Dysfunctional HDL: from structure-function-relationships to biomarkers

M Riwanto, L Rohrer, A von Eckardstein… - High Density …, 2015 - library.oapen.org
Reduced plasma levels of HDL-C are associated with an increased risk of CAD and
myocardial infarction, as shown in various prospective population studies. However, recent …

Reverse cholesterol transport: high-density lipoprotein's magnificent mile

PP Toth - Current atherosclerosis reports, 2003 - Springer
High-density lipoproteins (HDLs) are among the most structurally complex and functionally
versatile forms of circulating serum lipoproteins. HDLs undergo extensive enzymatic …

Molecular mechanisms responsible for the antiinflammatory and protective effect of HDL on the endothelium

GD Norata, AL Catapano - Vascular health and risk management, 2005 - Taylor & Francis
In addition to their role in reverse cholesterol transport, high-density lipoproteins (HDL) exert
several beneficial effects, including the prevention and correction of endothelial dysfunction …

Endothelial and antithrombotic actions of HDL

C Mineo, H Deguchi, JH Griffin, PW Shaul - Circulation research, 2006 - Am Heart Assoc
It is well recognized that high-density lipoprotein (HDL)-cholesterol is antiatherogenic and
serves a role in mediating cholesterol efflux from cells. However, HDL has multiple …

HDL-mediated mechanisms of protection in cardiovascular disease

A Kontush - Cardiovascular research, 2014 - academic.oup.com
Low plasma levels of HDL-cholesterol (HDL-C) represent a strong and independent risk
factor for cardiovascular disease. HDL particles display a wide spectrum of atheroprotective …