Objective—The purpose of this study was to define heterogeneity in the molecular profile of
lipids, including sphingomyelin and sphingosine-1-phosphate, among physicochemically …

Accumulation of cholesterol by macrophages, leading to their transformation into foam cells
is a key event in the initiation of atherosclerosis. As maintenance of cholesterol homeostasis …

Low high‐density lipoprotein (HDL)‐cholesterol levels are associated with an increased risk
of coronary artery disease (CAD) and myocardial infarction, which has triggered the …

Despite dramatic improvement in treatments for reducing risk for coronary heart disease
(CHD), it is still the leading cause of mortality in the developed world. In the past decade, a …

Although plasma concentrations of high-density lipoprotein (HDL) cholesterol correlate
inversely with the incidence of atherosclerotic cardiovascular disease, results from recent …

Aims/Hypothesis One of the hallmarks of diabetes is impaired endothelial function. Previous
studies showed that HDL can exert protective effects on endothelium stimulating NO …

crease in HDL, whereas hepatic overexpression of scavenger receptor (SR)-BI with gene
transfer reduces atherosclerosis, despite a major reduction in HDL levels. 47, 48 …

There are several well-documented functions of high-density lipoprotein (HDL) that may
explain the ability of these lipoproteins to protect against atherosclerosis. The best …

Low high-density lipoprotein cholesterol (HDL-C) levels are associated with incident
cardiovascular events; however, many therapies targeting increases in HDL-C have failed to …

Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …