Background: Peanut allergy is a life-threatening condition; there is currently no cure. While
whole allergen extracts are used for specific immunotherapy for many allergies, they can …

Recombinant hypoallergenic derivative is the next generation of tolerogen replacing the
natural allergen extract to increase safety and efficacy. Japanese cedar pollinosis is the …

Background Allergen‐derived (T cell epitope) peptides may be safer for immunotherapy
than native allergen, as they do not cross‐link immunoglobulin (Ig) E. However, HLA …

Plant-based edible vaccine has been shown to be effective for treatment of Japanese cedar
pollinosis. When rice seeds containing T-cell epitopes derived from cedar pollen allergens …

House dust mites are one of the most important allergen sources worldwide and affect
approximately 50% of asthmatic patients. Allergen-specific immunotherapy (AIT) is the only …

METHODS: Cockroach extracts were stored with e-aminocaproic acid (EACA), sucrose,
glycerol, pepstatin and aprotinin individually for 1, 3, 6 and 12 months at 48C, 258C and …

Background Cross-reactivity between soybean allergens and bovine caseins has been
previously reported. In this study we aimed to map epitopes of the major soybean allergen …

Peptide-based therapies are showing increasing potential for the development of vaccines
and in the treatment of many important diseases. We previously reported two peptide …

Background Clinical and experimental analyses indicate a pathognomonic role for allergen
IgE crosslinking through epitope–paratope interactions as a major initial step in the cascade …

In the development of a novel vaccine against atopic allergies, we have screened for
adjuvants that enhance the therapeutic antibody response against self immunoglobulin E …