Carbon dioxide modifies the morphology and function of mesothelial cells and facilitates transepithelial neuroblastoma cell migration

Y Yu, J Kuebler, S Groos, M Metzelder… - Pediatric surgery …, 2010 - Springer
Background The response of mesothelial cells to surgical trauma and bacterial
contamination is poorly defined. We have recently shown that CO 2 pneumoperitoneum …

Effects of CO2 pneumoperitoneum on peritoneal macrophage function and peritoneal metastasis in mice with gastric cancer

HX Luo, PW Yu, YX Hao, YL Zhao, Y Shi… - European Surgical …, 2012 - karger.com
Background: Whether laparoscopy with CO 2 pneumoperitoneum affects the peritoneal
metastasis of gastric cancer is a pressing question. In light of the important impact change in …

CO2 pneumoperitoneum increases systemic but not local tumor spread after intraperitoneal murine neuroblastoma spillage in mice

M Metzelder, J Kuebler, A Shimotakahara, G Vieten… - Surgical …, 2008 - Springer
Background Minimally invasive techniques are increasingly used for biopsy and resection of
neuroblastoma, but the impact on the behavior of spilled tumor cells is unknown. We aimed …

Carbon dioxide suppresses macrophage superoxide anion production independent of extracellular pH and mitochondrial activity

JF Kuebler, M Kos, NK Jesch, ML Metzelder… - Journal of pediatric …, 2007 - Elsevier
BACKGROUND: Superoxide anions released by activated macrophages during surgery are
considered to be responsible for local cellular damage. Application of CO2 …

Carbon dioxide pneumoperitoneum induces anti-inflammatory response and hepatic oxidative stress in young rats with bacterial peritonitis

CS Hsieh, YL Tain, YC Chen, K Chang… - Pediatric surgery …, 2011 - Springer
Purpose The aim of this study was to investigate the effects of carbon dioxide (CO 2)
pneumoperitoneum on the intra-abdominal spread of bacteria, the local and systemic …

Effect of CO2 pneumoperitoneum on intraperitoneal tumor growth in the animal model

S Köster, F Melchert, J Volz - Geburtshilfe und Frauenheilkunde, 1996 - europepmc.org
Clinical observations during recent years describe the increased occurrence of rapid
intraperitoneal metastases and an impairment of prognosis if a malignant tumour was …

p53 expression and apoptosis in liver and spleen during CO2 pneumoperitoneum

Y Arikan, M Tosun, V Şaykol, S Kalkan… - Langenbeck's archives of …, 2008 - Springer
Backgrounds and aims Laparoscopic surgery techniques have been increasingly preferred
to classic laparotomy by surgeons since 1987. However, this method has some important …

Impact of the surgical peritoneal environment on pre-implanted tumors on a molecular level: a syngeneic mouse model

S Matsuzaki, AS Azuar, G Mage, M Canis - Journal of Surgical Research, 2010 - Elsevier
BACKGROUND: We recently demonstrated that a CO2 pneumoperitoneum at either a high
or low IPP has few if any short term effects on peritoneal dissemination when tumors are well …

CO2 pneumoperitoneum does not enhance tumor growth and metastasis: Study of a rat cecal wall inoculation model

H Tomita, PW Marcello, JW Milsom, TL Gramlich… - Diseases of the colon & …, 2001 - Springer
INTRODUCTION: Although many studies have evaluated the effects of carbon dioxide
pneumoperitoneum on port site recurrence, little is known about its outcome on tumor …

Hyperthermic carbon dioxide pneumoperitoneum reinforces the inhibition of 5-FU on the proliferation and invasion of colon cancer

J Zhao, Y Lv, Y Cai, W Wei, C Yin… - Oncology …, 2017 - spandidos-publications.com
The effect of hyperthermic carbon dioxide (CO2) pneumoperitoneum in combination with 5-
fluorouracil (5-FU) on the proliferation and invasion of colon cancer was explored. Colon …