Neutrophil (PMN) mobilization to sites of insult is critical for host defense and requires
transendothelial migration (TEM). TEM involves several well-studied sequential adhesive …

Neutrophil (PMN) transepithelial migration (TEM) and accumulation in luminal spaces is a
hallmark of mucosal inflammation. TEM has been extensively modeled; however, the …

Inflammatory responses in the intestinal mucosa inevitably result in the recruitment of
neutrophils (polymorphonuclear leukocytes [PMNs]). Epithelial cells that line the mucosa …

A characteristic feature of gastrointestinal tract inflammatory disorders, such as inflammatory
bowel disease, is polymorphonuclear neutrophil (PMN) transepithelial migration (TEM) and …

Increased microvascular permeability to plasma proteins and neutrophil emigration are
hallmarks of innate immunity and key features of numerous inflammatory disorders …

Epithelial adhesion molecules play essential roles in regulating cellular function and
maintaining mucosal tissue homeostasis. Some form epithelial junctional complexes to …

BACKGROUND & AIMS: Acute inflammation of the intestine is associated with
transepithelial migration of polymorphonuclear leukocytes (PMNs) and epithelial wounds …

During acute inflammation, neutrophil recruitment into extravascular tissue requires
neutrophil tethering and rolling on cytokine-activated endothelial cells (ECs), tight adhesion …

The migration of neutrophils from the blood circulation to sites of infection or injury is a key
immune response and requires the breaching of endothelial cells (ECs) that line the inner …

Polymorphonuclear neutrophils (PMN s) are innate immune system cells that play an
essential role in eradicating invading pathogens. PMN migration to sites of …