Neutrophil infiltration into tissues is essential for host defense and pathogen clearance.
Although many of the signaling pathways involved in the transendothelial migration of …

Background Epithelial dysfunction and patient symptoms in inflammatory intestinal diseases
such as ulcerative colitis and Crohn's disease correlate with migration of neutrophils (PMN) …

Leukocyte recruitment into inflamed tissue proceeds in a cascade-like fashion. The first
contact of neutrophils with the endothelium is mediated by selectins and their …

During active intestinal inflammation granulocytes accumulate in the lumen of the gut where
they damage the epithelium through the release of various products such as reactive oxygen …

Macrophages in the gastrointestinal mucosa represent the largest pool of tissue
macrophages in the body. In order to maintain mucosal homeostasis, resident intestinal …

Hepatic neutrophil adhesion during endotoxemia is an integrin-independent, CD44-
dependent process. Because integrins function in other endotoxemic vasculatures, we used …

Interactions between the vascular endothelium and polymorphonuclear leukocytes (PMNs)
are central to PMN emigration into inflamed tissues, and to neutrophil–endothelial crosstalk …

Neutrophil (polymorphonuclear neutrophil) migration across epithelial barriers is a common
morphologic feature of many diseases. Previous studies show that PMN-epithelial …

Neutrophils migrate to sites of tissue damage, where they protect the host against
pathogens. Often, the cost of these neutrophil defenses is collateral damage to healthy …

Dysregulated neutrophil extravasation contributes to the pathogenesis of many inflammatory
disorders. Pericytes (PCs) have been implicated in the regulation of neutrophil …