In intestine, neutrophils are recruited in response to bacterial infiltration and their anti‐
cellular activities contribute to inflammatory bowel diseases. In contrast, little is known …

Background Inflammation-associated lymphangiogenesis (IAL) is frequently observed in
inflammatory bowel diseases. IAL is believed to limit inflammation by enhancing fluid and …

Conditioning-induced damage of the intestinal tract plays a critical role during the onset of
acute graft-versus-host disease (GVHD). Therapeutic interference with these early events of …

Neutrophils must follow both endogenous and bacterial chemoattractant signals out of the
vasculature and through the interstitium to arrive at a site of infection. By necessity, in the …

Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host
response to infection characterized by excessive neutrophil infiltration into vital organs. In …

Neutrophil (PMN) infiltration and associated release of serine proteases contribute to
epithelial injury during active phases of mucosal disorders such as inflammatory bowel …

The transmigration of polymorphonuclear leukocytes (PMNs; neutrophils) into the intestinal
lumen is a classical phenomenon associated with a wide variety of disease states, including …

The vascular endothelium plays an integral part in the inflammatory response. During the
acute phase of inflammation, endothelial cells (ECs) are activated by host mediators or …

Polymorphonuclear neutrophil (PMN) extravasation requires selectin-mediated tethering,
intercellular adhesion molecule-1 (ICAM-1)–dependent firm adhesion, and …

Human neutrophils respond to multiple chemoattractants to guide their migration from the
vasculature to sites of infection and injury, where they clear pathogens and amplify …