The microvascular endothelium serves as the major barrier that controls the transport of
blood constituents across the vessel wall. Barrier leakage occurs during infection or sterile …

Neutrophils are professional phagocytes that constitute the first line of defense in humans.
The primary function of neutrophils is to eliminate invading pathogens through oxidative and …

The lamina propria of the gastrointestinal mucosa contains the largest population of
mononuclear phagocytes in the body, yet little is known about the cellular mechanisms that …

Neutrophils play an essential role in host defense against infection or injury. While
neutrophil activation is necessary for pathogen clearance and tissue repair, a hyperactive …

In Crohn's disease and ulcerative colitis patients, the numbers of neutrophils recovered from
stool directly correlates with the severity of disease, implying that neutrophils in the lumen …

In vivo, leukocyte transendothelial migration (TEM) occurs at endothelial cell junctions
(paracellular) and nonjunctional (transcellular) locations, whereas in vitro models report that …

We examined the ability of monocytes (MΦ) activated by bacterial products to alter epithelial
physiology. Confluent monolayers of the T84 colonic epithelial cell line were grown on filter …

Transport of macromolecules and transmigration of leukocytes across vascular endothelium
are regulated by a tight molecular junction, but the mechanisms by which these two …

Microtubules (MTs) are critically involved in the transport of material within cells, but their
roles in chemotactic leukocyte motility and effector functions are still obscure. Resting …

Neutrophils are recognised to play a pivotal role at the interface between innate and
acquired immunities following their recruitment to inflamed tissues and lymphoid organs …