Significance: Acute pancreatitis is an inflammatory disease of exocrine pancreas that carries
considerable morbidity and mortality; its pathophysiology remains poorly understood. During …

Acute pancreatitis has an incidence of approximately 40 cases per year per 100,000 adults.
Although usually self-limiting, 10% to 20% of afflicted patients will progress to severe …

Acute pancreatitis is a disease of variable severity in which some patients experience mild,
self‐limited attacks while others manifest a severe, highly morbid, and frequently lethal …

The underlying mechanisms involved in the pathogenesis of acute pancreatitis are ill
understood. The mortality rate of this disease has not significantly improved over the past …

Acute pancreatitis is a potentially life threatening disease. The spectrum of severity of the
illness ranges from mild self‐limiting disease to a highly fatal severe necrotizing pancreatitis …

Acute pancreatitis (AP) is a common acute inflammatory process of the pancreas that affects
approximately 80,000 individuals in the United States annually [1]. The clinical course of AP …

Acute pancreatitis (AP) is an acute inflammatory process of the pancreas that is associated
with variable involvement of pancreatic/peripancreatic tissue and one or more organ …

Acute pancreatitis (AP) is a potentially lethal inflammatory disease that lacks specific
therapy. Damaged pancreatic acinar cells are believed to be the site of AP initiation. The …

The onset of severe acute pancreatitis (SAP) is clinically harmful as it may rapidly progress
from a local pancreatic inflammation into proemial systemic inflammatory reactions. Patients …

Recent advances challenge the long-believed trypsin-centered understanding of
pancreatitis. It is becoming increasingly clear that activation of intense inflammatory …