Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and
chronic kidney disease. NLRX1 is a receptor of the innate immune system that is …

Innate immunity activates the corresponding immune response relying on multiple pattern
recognition receptors (PRRs) that includes pattern recognition receptors (PRRs), like NOD …

NLRX1 is a member of the of the Nod-like receptor (NLR) family, and it represents a unique
pattern recognition molecule (PRM) as it localizes to the mitochondrial matrix in resting …

NLRX1 is a mitochondrial Nod-like receptor (NLR) protein whose function remains
enigmatic. Here, we observed that NLRX1 expression was glucose-regulated and blunted …

NLRC5 is a member of the NLR family that acts as a transcriptional activator of MHC class I
genes. In line with the function of several related NLR proteins in innate immune responses …

LRH-1 (liver receptor homolog-1/NR5a2) is an orphan nuclear receptor, which regulates
glucose and lipid metabolism, as well as intestinal inflammation via the transcriptional …

NLRX1 Has a Tail to Tell Page 1 Immunity Previews NLRX1 Has a Tail to Tell Tsan Sam Xiao1,*
and Jenny P.-Y. Ting2,* 1Structural Immunobiology Unit, Laboratory of Immunology, National …

Nucleotide-binding domain and leucine-rich repeat containing (NLR) family are intracellular
sentinels of cytosolic homeostasis that orchestrate immune and inflammatory responses in …

Background Regulation of cell death during neurodegeneration is one of the key factors that
play a role in the speed at which a disease progresses. Out of several cellular pathways …

The nucleotide‐binding domain leucine‐rich repeat containing receptors (NLRs) are a
family of evolutionarily conserved proteins. Several members of NLRs, notably NLRP1 …