In this issue of Immunity, Allen et al.(2011) and Xia et al.(2011) provide in vivo and
biochemical evidence that NLRX1, a member of the nucleotide binding domain and leucine …

Nucleotide oligomerization domain–like receptor X1 (NLRX1) has been implicated in viral
response, cancer progression, and inflammatory disorders; however, its role as a dual …

NLRC3, a member of the NLR family, has been reported as a negative regulator of
inflammatory signaling pathways in innate immune cells. However, the direct role of NLRC3 …

NOD-like receptors (NLRs) are a family of intracellular pattern recognition receptors (PRRs)
that play critical roles in innate immunity against pathogens infection. NLRC5, the largest …

An increased level of proinflammatory cytokines, including TNF-α in tumor microenvironment
regulates the bioenergetic capacity, immune evasion and survival of cancer cells. Emerging …

Autoinflammatory syndromes cause sterile inflammation in the absence of any signs of
autoimmune responses. Familial cold autoinflammatory syndrome (FCAS) is characterized …

Mitochondrial NLRX1 is a member of the family of nucleotide-binding domain and leucine-
rich-repeat-containing proteins (NLRs) that mediate host innate immunity as intracellular …

The innate immune system is the first line of defense against microorganisms and is
conserved in plants and animals. The nucleotide-binding domain, leucine rich containing …

The innate immune system is the first line of defense for the host against any microbial
attack. It can quickly identify microorganisms and produce an immune response, removing …

NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat)
family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …