NOD-like receptors (NLRs) are a class of cytoplasmic pattern-recognition receptors.
Although most NLRs play some role in immunity, their functions range from regulating …

Mammalian nucleotide-binding domain leucine-rich repeat containing proteins (NLRs) are
important pattern-recognition receptors, still the function of many NLRs remains poorly …

Increasing evidence suggests that inflammation and apoptosis are involved in the
development of acute myocardial ischemia (AMI). Nucleotide-binding oligomerization …

For the first time there is now clear biochemical and biophysical evidence indicating that
members of the nucleotide-binding domain and leucine-rich repeat containing (NLR) family …

Nod-like receptors (NLRs) are intracellular sensors that respond to a variety of pathogen
and intracellular danger signals to induce innate immune responses. NLRC5 has recently …

NLRP6, a member of the nucleotide-binding domain, leucine-rich repeat-containing (NLR)
innate immune receptor family, regulates inflammation and host defense against …

B-cell receptor (BCR) signaling plays a critical role in B-cell activation and humoral
immunity. In this study, we discovered a critical function of leucine-rich repeat kinase 1 …

Appropriate immune responses require a fine balance between immune activation and
attenuation. NLRC3, a non-inflammasome-forming member of the NLR innate immune …

Nod-like receptors (NLRs) are intracellular sentinel proteins that are implicated in the
detection of microbes and danger signals, thereby controlling several key innate immune …

Both NLRC3 and NOD1 belong to regulatory NLR subfamily based on their best-
characterized function. In mammals, NLRC3 was reported to function by attenuating …