Members of the family of NOD-like receptors (NLRs) play essential roles in innate immunity
by detecting intracellular 'pathogen-associated molecular patterns'(PAMPs) and 'danger …

The NLRP3 inflammasome is a key component of the innate immune system that induces
pro-inflammatory cytokine production and cell death. Although NLRP3 is activated by many …

The NOD-like receptor family, pyrin domain containing-3 (NLRP3) inflammasome has been
implicated in renal inflammation and fibrosis. However, the biological function of …

Nod-Like Receptor (NLR) is the largest family of Pathogen Recognition Receptors (PRRs)
that patrols the cytosolic environment. NLR engagement drives caspase-1 activation that …

NOD-like Receptors (NLRs) are a large family of 22 intracellular proteins in humans.
Although NLRs are structurally homologous to each other, they perform a diverse array of …

NLRP1, while the first inflammasome described, has only recently begun to gain significant
attention in disease pathology, inflammation research, and potentially, as a therapeutic …

Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

Although best known for inducing inflammasome formation and pyroptosis in myeloid cells,
increasing evidence highlights additional roles for Nod-like receptors (NLR) in …

Intracellular NOD-like receptor (NLR) proteins are believed to play important roles in innate
immune detection or immune regulation, but only a few NLR proteins are functionally …

NLRC5 is a transcriptional regulator of MHC class I (MHCI), which maintains high MHCI
expression particularly in T cells. Recent evidence highlights an important NK–T-cell …