Mutations in the multidomain protein Leucine-rich-repeat kinase 2 (LRRK2) have been
identified as a genetic risk factor for both sporadic and familial Parkinson's disease (PD) …

Septic shock is one of the most significant health concerns across the world, involving hypo-
perfusion and defects in tissue energy. The current study investigates the role of NLR family …

The nucleotide binding domain and leucine-rich repeat-containing (NLR) family of proteins
is known to activate innate immunity, and the inflammasome-associated NLRs are prime …

Significance: Persistent nonmicrobial tissue injury leads to the nonlinear activation of
integrated wound-healing pathways. In chronic cardiovascular diseases, local tissue …

Microglia are phagocytic cells that form the basis of the brain's immune system. They derive
from primitive macrophages that migrate into the brain during embryogenesis, but the …

Missense mutations in the nucleotide-binding oligomerization domain (NOD)-like receptor
pyrin domain containing family of gene 12 (Nlrp12) are associated with periodic fever …

IL-1β and IL-18 are pro-inflammatory cytokines that play a critical role in the response to a
diverse array of injuries and infections. Accordingly, the production of these potent cytokines …

NOD-like receptors represent an important class of germline-encoded pattern recognition
receptors that play key roles in the regulation of inflammatory signalling pathways. They …

NOD-like receptors (NLRs) are a family of intracellular proteins that play critical roles in
innate immunity against microbial infection. NLRC5, the largest member of the NLR family …

The current view of cytoplasmic RNA-mediated innate immune signaling involves the
differential activation of the RNA helicases retinoic acid-inducible gene 1 (RIG-I), melanoma …