From pattern classification to stratification: towards conceptualizing the heterogeneity of Autism Spectrum Disorder

T Wolfers, DL Floris, R Dinga, D van Rooij… - Neuroscience & …, 2019 - Elsevier
Pattern classification and stratification approaches have increasingly been used in research
on Autism Spectrum Disorder (ASD) over the last ten years with the goal of translation …

[HTML][HTML] Validation strategies for subtypes in psychiatry: A systematic review of research on autism spectrum disorder

JAA van Rentergem, MK Deserno, HM Geurts - Clinical Psychology …, 2021 - Elsevier
Heterogeneity within autism spectrum disorder (ASD) is recognized as a challenge to both
biological and psychological research, as well as clinical practice. To reduce unexplained …

An overview of autism spectrum disorder, heterogeneity and treatment options

A Masi, MM DeMayo, N Glozier, AJ Guastella - Neuroscience bulletin, 2017 - Springer
Since the documented observations of Kanner in 1943, there has been great debate about
the diagnoses, the sub-types, and the diagnostic threshold that relates to what is now known …

Autism spectrum disorder: defining dimensions and subgroups

O Ousley, T Cermak - Current developmental disorders reports, 2014 - Springer
Autism spectrum disorder (ASD) is a behaviorally defined neurodevelopmental disorder
associated with the presence of social-communication deficits and restricted and repetitive …

Syndromic autism spectrum disorders: moving from a clinically defined to a molecularly defined approach

BA Fernandez, SW Scherer - Dialogues in clinical neuroscience, 2017 - Taylor & Francis
Autism spectrum disorder (ASD) encompasses a group of neurodevelopmental conditions
diagnosed solely on the basis of behavioral assessments that reveal social deficits …

Toward neurosubtypes in autism

SJ Hong, JT Vogelstein, A Gozzi, BC Bernhardt… - Biological …, 2020 - Elsevier
There is a consensus that substantial heterogeneity underlies the neurobiology of autism
spectrum disorder (ASD). As such, it has become increasingly clear that a dissection of …

Annual Research Review: Re‐thinking the classification of autism spectrum disorders

C Lord, RM Jones - Journal of Child Psychology and Psychiatry, 2012 - Wiley Online Library
Background: The nosology of autism spectrum disorders (ASD) is at a critical point in history
as the field seeks to better define dimensions of social‐communication deficits and …

Genesis, modelling and methodological remedies to autism heterogeneity

J Rabot, EM Rødgaard, R Joober, G Dumas… - Neuroscience & …, 2023 - Elsevier
Diagnostic criteria used in autism research have undergone a shift towards the inclusion of a
larger population, paralleled by increasing, but variable, estimates of autism prevalence …

Quantifying the optimal structure of the autism phenotype: A comprehensive comparison of dimensional, categorical, and hybrid models

H Kim, C Keifer, C Rodriguez-Seijas, N Eaton… - Journal of the American …, 2019 - Elsevier
Objective The two primary—seemingly contradictory—strategies for classifying child
psychiatric syndromes are categorical and dimensional; conceptual ambiguities appear to …

DSM-5 and autism spectrum disorders (ASDs): an opportunity for identifying ASD subtypes

R Grzadzinski, M Huerta, C Lord - Molecular autism, 2013 - Springer
The heterogeneous clinical presentations of individuals with autism spectrum disorders
(ASDs) poses a significant challenge for sample characterization and limits the …