Epidemics and pandemics of respiratory disease consistent with influenza have been
recorded since the 16th century. 1, 2 During the 19th century, influenza was attributed to …

Influenza is a major respiratory pathogen causing annual outbreaks and occasional
pandemics. Influenza vaccination is the major method of prophylaxis. Currently annual …

Influenza is a modern day plague. In the young, the clinical picture is classical, but in the
elderly, the disease may go unsuspected until complications such as pneumonia develop …

Influenza viruses, particularly influenza A viruses, cause a substantial degree of morbidity
and mortality worldwide and are a persistent threat to global health. Influenza viruses have 2 …

Despite all we have learned since 1918 about influenza virus and immunity, available
influenza vaccines remain inadequate to control outbreaks of unexpected strains. Universal …

Universal influenza virus vaccines: need for clinical trials | Nature Immunology Skip to main
content Thank you for visiting nature.com. You are using a browser version with limited support …

Introduction. A number of pharmaceutical and biotechnology companies, hospitals and
academic research institutions around the world are pursuing the development of a …

Publisher Summary This chapter discusses immunology of influenza virus infections,
limitations of current vaccines, and approaches for developing highly effective influenza …

Fears of a potential pandemic due to A (H5N1) viruses have focussed new attention on our
current vaccines, their shortcomings, and concerns regarding global vaccine supply in a …

An influenza pandemic represents one of the greatest acute infectious threats to health. The
1918–1919 influenza pandemic caused an estimated 500,000 deaths in the United States …