Therapeutic targets for the management of peripheral nerve injury-induced neuropathic pain

A Singh Jaggi, N Singh - … Formerly Current Drug Targets-CNS & …, 2011 - ingentaconnect.com
Neuropathic pain is a debilitating form of treatment resistant chronic pain and responds
poorly to the clinically available therapies. Studies from animal models of neuropathic pain …

[HTML][HTML] Neuropathic pain models and outcome measures: a dual translational challenge

RDE Sewell - Annals of Translational Medicine, 2018 - ncbi.nlm.nih.gov
The phenomenon of pain may be neuropathic in nature and it invariably stems from disease
or injury affecting the somatosensory system (1, 2). Neuropathic pain is usually a chronic …

[PDF][PDF] The physiology of pain: an update and review of clinical relevance

DWN Dissanayake, DMD Dissanayake - 2015 - dl.nsf.gov.lk
Pain, defined as a symptom, sign or a syndrome, has been researched extensively
compared to any other area in neurophysiology. This short review aims to explain the …

Recent developments in neuropathic pain mechanisms: implications for treatment

W Rahman, AH Dickenson - Reviews in Pain, 2011 - journals.sagepub.com
• Neuropathic pain is defined as “pain arising as a direct consequence of a lesion or disease
affecting the somatosensory system”.• Characteristic symptoms include an increased evoked …

Neuropathic pain: From actual pharmacological treatments to new therapeutic horizons

M Thouaye, I Yalcin - Pharmacology & Therapeutics, 2023 - Elsevier
Neuropathic pain, caused by a lesion or disease affecting the somatosensory system, affects
between 3 and 17% of the general population. The treatment of neuropathic pain is …

Neuropathic pain: symptoms, models, and mechanisms

S Beggs, MW Salter - Drug development research, 2006 - Wiley Online Library
Peripheral neuropathic pain is the most debilitating of all clinical pain syndromes and affects
a large and growing number of people worldwide. There are diverse causes for peripheral …

Neuropathic pain: sensory nerve injury or motor nerve injury?

XG Liu, RP Pang, LJ Zhou, XH Wei, Y Zang - Translational Research in …, 2016 - Springer
Peripheral nerve injury often induces chronic neuropathic pain. Peripheral nerve is
consisted of sensory fibers and motor fibers, it is questioned injury to which type of fibers is …

Individualized pharmacological treatment of neuropathic pain

SM Helfert, M Reimer, J Höper… - Clinical Pharmacology & …, 2015 - Wiley Online Library
Patients with the same disease may suffer from completely different pain symptoms yet
receive the same drug treatment. Several studies elucidate neuropathic pain and treatment …

Central neuropathic pain

J Rosner, DC de Andrade, KD Davis… - Nature Reviews …, 2023 - nature.com
Central neuropathic pain arises from a lesion or disease of the central somatosensory
nervous system such as brain injury, spinal cord injury, stroke, multiple sclerosis or related …

Neuropathic pain: are we out of the woods yet?

J Cavenagh, P Good, P Ravenscroft - Internal medicine journal, 2006 - Wiley Online Library
Patients suffering from neuropathic pain continue to pose challenges in clinical practice.
This descriptive review discusses the continuing debate on the definition and concerns …