Pancreatic islet development is impaired in mice lacking EGFRs (epidermal growth factor
receptors). Even partial tissue-specific attenuation of EGFR signalling in the islets leads to …

Epidermal growth factor receptor (EGF-R) signaling is essential for proper fetal development
and growth of pancreatic islets, and there is also evidence for its involvement in β-cell signal …

Pancreatic acini and islets are believed to differentiate from common ductal precursors
through a process requiring various growth factors. Epidermal growth factor receptor (EGF …

Aims/hypothesis Epidermal growth factor receptor (EGFR) signalling is essential for the
proper fetal development of pancreatic islets and in the postnatal formation of an adequate …

The neuregulin (NRG)/epidermal growth factor (EGF) family of growth factors consists of
several ligands that specifically activate four erbB receptor-tyrosine kinases, namely erbB-1 …

A thorough understanding of the signaling pathways involved in the regulation of β cell
proliferation is an important initial step in restoring β cell mass in the diabetic patient. Here …

The molecular mechanisms of β-cell compensation to metabolic stress are poorly
understood. We previously observed that nutrient-induced β-cell proliferation in rats is …

Betacellulin (BTC) purified from mouse jl cell tumor (jITC-3) is a new member of the
epidermal growth factor (EGF) family which can bind receptor tyrosine kinase, EGF receptor …

Aims/hypothesis EGF receptor (EGFR) signalling is required for normal beta cell
development and postnatal beta cell proliferation. We tested whether beta cell proliferation …

Given the inherent therapeutic potential of the morphogenetic plasticity of adult human islets,
the identification of factors controlling their cellular differentiation is of interest. The …