Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases
(IBD) and have pathophysiological processes such as bowel necrosis and enteric neurons …

Anti-tumor necrosis factor (TNF) antibodies are successfully used in the therapy of
inflammatory bowel diseases (IBD). However, the molecular mechanism of action of these …

Background Tumor necrosis factor alpha (TNFα) is a proinflammatory cytokine and an
important mediator in the pathophysiology of inflammatory bowel disease (IBD). The effects …

Anti-tumor necrosis factor (TNF) antibodies are powerful therapeutic agents for the treatment
of Crohn's disease. TNF has diverse proinflammatory effects within the intestinal mucosa …

Biological treatment with tumor necrosis factor (TNF) inhibitors is successful in the
management of inflammatory bowel disease (IBD). All TNF inhibitors antagonize the pro …

The inflammatory bowel diseases frequently require surgery because of intestinal
complications. Animal models of inflammatory bowel disease, in particular those that …

Tumor Necrosis Factor Inhibitors for Inflammatory Bowel Disease | NEJM Skip to main content
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Background—Tumour necrosis factor (TNF) α and TNF-β are soluble ligands binding to TNF
receptors with similar activities; soluble TNF receptors neutralise TNF activity by acting as …

Durch umfangreiche klinische und grundlagenwissenschaftliche Untersuchungen konnte
die zentrale Rolle des Tumornekrosefaktors-α für die Pathogenese chronisch entzündlicher …

Several TNF antagonists, mainly monoclonal antibodies, have shown to be efficacious in the
therapy of Crohn's disease. Despite the fact that they have been used for over a decade …