Tumour necrosis factor TNF) plays a crucial role in the initiation and amplification of
inflammatory reactions. These properties thus make TNF an obvious target for modulating …

The pathogenesis and treatment of inflammatory bowel disease (IBD) have been recently
advanced, while it is still challenged with high morbidity and poor prognosis. Infliximab, a …

Monoclonal antibodies to tumor necrosis factor (TNF) have become a mainstay of the
therapeutic armamentarium in inflammatory bowel disease (IBD) over the last 15 years …

Objective. The immune characterization of ulcerative colitis (UC) has been unclear and
controversial. One possible explanation for the discrepancies between earlier cytokine …

In the past decade, advances in the understanding of the pathogenesis of inflammatory
bowel disease have permitted the development of agents directed against rational …

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory
bowel diseases (IBDs). The overall objective was to better understand and explore primary …

This second section of the first ECCO pathogenesis workshop on anti-TNF therapy failures
in inflammatory bowel diseases addresses the biological roles of TNFα and the effects and …

The intestinal epithelium represents an exquisite complex combination of specialized
cellular components, structural organization, as well as fine-tuned maintenance and renewal …

Background: The role of tumour necrosis factor‐α in the pathogenesis of inflammatory bowel
disorders is well‐known and is underscored by the effectiveness of antitumour necrosis …

OBJECTIVES: A primary defect of the tight junctions and, hence, increased intestinal
epithelial permeability has been proposed as a basic pathogenic event in Crohn's disease …