Molecular architecture and domain arrangement of the placental malaria protein VAR2CSA suggests a model for carbohydrate binding
MC Bewley, L Gautam, MG Jagadeeshaprasad… - Journal of Biological …, 2020 - ASBMB
VAR2CSA is the placental-malaria–specific member of the antigenically variant Plasmodium
falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of …
falciparum erythrocyte membrane protein 1 (PfEMP1) family. It is expressed on the surface of …
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria
TM Clausen, S Christoffersen, M Dahlbäck… - Journal of Biological …, 2012 - ASBMB
Malaria is a major global health problem. Pregnant women are susceptible to infection
regardless of previously acquired immunity. Placental malaria is caused by parasites …
regardless of previously acquired immunity. Placental malaria is caused by parasites …
[HTML][HTML] Differential recognition of terminal extracellular Plasmodium falciparum VAR2CSA domains by sera from multigravid, malaria-exposed Malian women
MA Travassos, D Coulibaly, JA Bailey… - The American Journal …, 2015 - ncbi.nlm.nih.gov
The Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediates
parasite sequestration in small capillaries through tissue-specific cytoadherence. The best …
parasite sequestration in small capillaries through tissue-specific cytoadherence. The best …
A new method for sequencing the hypervariable Plasmodium falciparum gene var2csa from clinical samples
Background VAR2CSA, a member of the Plasmodium falciparum erythrocyte membrane
protein 1 (PfEMP1) family, mediates the binding of P. falciparum-infected erythrocytes to …
protein 1 (PfEMP1) family, mediates the binding of P. falciparum-infected erythrocytes to …
A conformational epitope in placental malaria vaccine antigen VAR2CSA: What does it teach us?
JYA Doritchamou, JP Renn, L Hviid, PE Duffy - PLoS Pathogens, 2023 - journals.plos.org
VAR2CSA is the Plasmodium falciparum variant surface antigen that mediates binding of
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
infected erythrocytes to chondroitin sulfate A (CSA) and their sequestration in intervillous …
Can any lessons be learned from the ambiguous glycan binding of PfEMP1 domains?
M Dahlbäck, MA Nielsen, A Salanti - Trends in parasitology, 2010 - cell.com
Pregnancy-associated malaria (PAM) is caused by Plasmodium falciparum-infected
erythrocytes (IEs) accumulating in the placenta and has dire consequences for both mother …
erythrocytes (IEs) accumulating in the placenta and has dire consequences for both mother …
Identification of glycosaminoglycan binding regions in the Plasmodium falciparum encoded placental sequestration ligand, VAR2CSA
M Resende, MA Nielsen, M Dahlbäck, SB Ditlev… - Malaria Journal, 2008 - Springer
Background Pregnancy malaria is caused by Plasmodium falciparum-infected erythrocytes
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
binding the placental receptor chondroitin sulfate A (CSA). This results in accumulation of …
Immunization with VAR2CSA-DBL5 Recombinant Protein Elicits Broadly Cross-Reactive Antibodies to Placental Plasmodium falciparum-Infected Erythrocytes
M Avril, MM Cartwright, MJ Hathaway… - Infection and …, 2010 - Am Soc Microbiol
Pregnancy-associated malaria is a severe clinical syndrome associated with the
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Placental …
Functional and immunological characterization of the var2CSA-DBL5ɛ domain of a placental Plasmodium falciparum isolate
S Gangnard, NGT Ndam, S Gnidehou… - Molecular and …, 2010 - Elsevier
Pregnancy-associated malaria (PAM) arises from sequestration of Plasmodium falciparum-
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …
parasitized erythrocytes (PE) in the placenta, leading to chronic symptoms in the expectant …
Full-length extracellular region of the var2CSA variant of PfEMP1 is required for specific, high-affinity binding to CSA
Pregnancy-associated malaria (PAM) is a serious consequence of sequestration of
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …
Plasmodium falciparum-parasitized erythrocytes (PE) in the placenta through adhesion to …