Importance Reanalyses of randomized clinical trial (RCT) data may help the scientific
community assess the validity of reported trial results. Objectives To identify published …

Real-world data (RWD) and the derivations of these data into real-world evidence (RWE)
are rapidly expanding from informing healthcare decisions at the patient and health system …

Objectives Risk-of-bias assessment is a central component of systematic reviews, but little
conclusive empirical evidence exists on the validity of such assessments. In the context of …

Objective To identify variations in outcomes and results across reports of randomized clinical
trials (RCTs). Study Design and Setting Eligible RCTs examined gabapentin for neuropathic …

Background Clinical trial registries can improve the validity of trial results by facilitating
comparisons between prospectively planned and reported outcomes. Previous reports on …

High-quality randomized clinical trials (RCTs) occupy the highest position on the evidence
pyramid, either as standalone studies or as part of meta-analyses. However, the …

ALTHOUGH RANDOMIZED CLINICAL TRIALS (RCTS) ARE the bedrock for establishing
which interventions are efficacious, there is increasing recognition that they cannot address …

Randomized controlled trials (RCTs) are conducted under idealized and rigorously
controlled conditions that may compromise their external validity. A literature review was …

The scientific community and decision‐makers are increasingly concerned about
transparency and reproducibility of epidemiologic studies using longitudinal healthcare …

Several approaches have been proposed recently to accelerate the pathway from drug
discovery to patient access. These include novel designs such as using controls external to …