ContextSelective eligibility criteria of randomized controlled trials (RCTs) are vital to trial
feasibility and internal validity. However, the exclusion of certain patient populations may …

Objectives To evaluate how often reproducible research practices, which allow others to
recreate the findings of studies, given the original data, are used in systematic reviews (SRs) …

Objectives To document reporting of study characteristics of randomized controlled trials
(RCTs) in the four leading general medical journals and to appraise the generalizability of …

OBJECTIVE: This article is to establish recommendations for conducting quantitative
synthesis, or meta-analysis, using study-level data in comparative effectiveness reviews …

ContextOngoing efforts to improve the quality of reporting for randomized controlled trials
(RCTs) include the Consolidated Standards of Reporting Trials (CONSORT) statement. We …

THE INCREASING AVAILABILITY OF ELECTRONIC HEALTH data combined with federal
investment has stimu-lated an expansion in observational clinical research. 1 Observational …

Objectives To assess the reliability of the Cochrane Risk of Bias (ROB) tool between
individual raters and across consensus agreements of pairs of reviewers and examine the …

Integrating Randomized Comparative Effectiveness Research with Patient Care | NEJM Skip to
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Methods| We conducted a cross-sectional analysis of clinical trials for which the primary
results were published between July 1, 2010, and June 30, 2011, in Medlineindexed, high …

Background Meta-analyses including a limited number of patients and events are prone to
yield overestimated intervention effect estimates. While many assume bias is the cause of …