Objective To provide guidance on how systematic review authors, guideline developers, and
health technology assessment practitioners should approach the use of the risk of bias in …

Objectives The objective of this study was to analyze the features of registry-based
randomized trials (rRCTs). Study Design and Setting We systematically searched PubMed …

Randomized controlled trial results are needed for developing guidelines, payment rules,
and quality-of-care measures; however, 2 phenomena reduce the usefulness of randomized …

Randomized clinical trials often serve the purpose of assessing the efficacy and safety of a
compound. By combining real-world evidence and randomization, pragmatic randomized …

Background Classically, randomised controlled trials (RCTs) are considered the gold
standard for demonstrating product efficacy for the regulatory approval of medicines …

OBJECTIVE: Statisticians have criticized the use of significance testing to compare the
distribution of baseline covariates between treatment groups in randomized controlled trials …

Human protection policies require favorable risk–benefit judgments prior to launch of clinical
trials. For phase I and II trials, evidence for such judgment often stems from preclinical …

Randomized Clinical Trials (RCTs) remain the gold standard for determining the utility of
pharmaceuticals especially from a safety and efficacy standpoint. However, restrictive entry …

Confounding by indication poses a significant threat to the validity of nonexperimental
studies assessing effectiveness and safety of medical interventions. While no different from …

Extensive resources have been invested in this field: they include the set-up of disease
registries and clinical databases at regional, national or international levels; the promotion of …