Srgap2 suppression ameliorates retinal ganglion cell degeneration in mice

YJ Gan, Y Cao, ZH Zhang, J Zhang… - Neural Regeneration …, 2023 - journals.lww.com
Abstract Slit-Robo GTPase-activating protein 2 (SRGAP2) plays important roles in axon
guidance, neuronal migration, synapse formation, and nerve regeneration. However, the …

Dynamic expression of srGAP2 in cell nuclei and cytoplasm during the differentiation of rat neural stem cells in vitro

Q Jiao, L Wang, Z Zhang, Y Wang… - Molecular …, 2016 - spandidos-publications.com
Abstract Different SLIT-ROBO Rho GTPase-activating proteins (srGAPs) have different levels
of expression and diverse functions during neural development. Although srGAP2 is …

[HTML][HTML] GPR3 expression in retinal ganglion cells contributes to neuron survival and accelerates axonal regeneration after optic nerve crush in mice

S Masuda, S Tanaka, H Shiraki, Y Sotomaru… - Neurobiology of …, 2022 - Elsevier
Glaucoma is an optic neuropathy and is currently one of the most common diseases that
leads to irreversible blindness. The axonal degeneration that occurs before retinal ganglion …

S1PR1 signaling attenuates apoptosis of retinal ganglion cells via modulation of cJun/Bim cascade and Bad phosphorylation in a mouse model of glaucoma

D Basavarajappa, V Gupta, R Vander Wall… - FASEB …, 2023 - researchers.mq.edu.au
Glaucoma is a complex neurodegenerative disease characterized by optic nerve damage
and apoptotic retinal ganglion cell (RGC) death, and is the leading cause of irreversible …

[HTML][HTML] Inhibition of heat shock protein B8 alleviates retinal dysfunction and ganglion cells loss via autophagy suppression in mouse axonal damage

F Xie, Z Li, N Yang, J Yang, D Hua… - … & Visual Science, 2022 - jov.arvojournals.org
Purpose: Heat shock protein B8 (HspB8) can be upregulated rapidly in many pathologic
processes, but its role in traumatic optic neuropathy remains unclear. In this study, we …

Zebrafish models of human-duplicated SRGAP2 reveal novel functions in microglia and visual system development

JM Uribe-Salazar, G Kaya, KC Weyenberg, B Radke… - bioRxiv, 2024 - biorxiv.org
The expansion of the human SRGAP2 family, resulting in a human-specific paralog
SRGAP2C, likely contributed to altered evolutionary brain features. The introduction of …

AAV2-mediated expression of HspB1 in RGCs prevents somal damage and axonal transport deficits in a mouse model of ocular hypertension

MH Nam, RB Nahomi, MB Pantcheva… - … Vision Science & …, 2022 - tvst.arvojournals.org
Purpose: Ocular hypertension is a significant risk factor for vision loss in glaucoma caused
by the death of retinal ganglion cells (RGCs). We investigated whether small heat shock …

Sphingosine 1‐phosphate receptor 1 is required for retinal ganglion cell survival after optic nerve trauma

S Joly, V Pernet - Journal of Neurochemistry, 2016 - Wiley Online Library
In this study, we used a classical optic nerve injury model to address the function of the
sphingosine 1‐phosphate (S1P)–S1P receptor (S1PR) axis in retinal ganglion cell (RGC) …

Transcriptomic analysis reveals that granulocyte colony-stimulating factor trigger a novel signaling pathway (taf9-p53-triap1-casp3) to protect retinal ganglion cells …

RK Tsai, KL Lin, CT Huang, YT Wen - International Journal of Molecular …, 2022 - mdpi.com
Optic nerve head (ONH) infarct can result in progressive retinal ganglion cell (RGC) death.
The granulocyte colony-stimulating factor (GCSF) protects the RGC after ON infarct …

Astrocyte derived TSP2 contributes to synaptic alteration and visual dysfunction in retinal ischemia/reperfusion injury

T Hu, S Meng, Q Zhang, S Song, C Tan, J Huang… - Cell & Bioscience, 2022 - Springer
Background Despite current intervention measures/therapies are able to ameliorate
neuronal death following retinal injuries/diseases, the recovery of visual function remains …