Reason for posting: Coxibs, the class of NSAIDs that selectively inhibit cyclooxygenase 2
(COX-2), were designed to reduce joint pain and inflammation without causing the gastric …

NSAIDs are extensively used worldwide; nonetheless, they are associated with adverse
gastrointestinal (GI) effects. COX-2 inhibitors (coxibs) have been developed to reduce pain …

Background Studies showing that drugs that inhibit cyclooxygenase-2 (COX-2) reduce the
number of colorectal adenomas in animals and patients with familial adenomatous …

BACKGROUND: The cyclooxygenase-2 (COX-2) selective nonsteroidal antiinflammatory
drugs (NSAIDs) celecoxib and rofecoxib (before its removal) are marketed as having fewer …

Background Selective cyclooxygenase-2 (COX-2) inhibitors have come under scrutiny
because of reports suggesting an increased cardiovascular risk associated with their use …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are nonselective inhibitors of
cyclooxygenase (COX) isoforms COX-1 and COX-2. NSAIDs have analgesic and anti …

Background—Cyclooxygenase-2 (COX-2) inhibitors have been shown to reduce colorectal
adenomas but have been associated with increased cardiovascular risk. Methods and …

Nonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for substantial morbidity and
mortality as a result of the complications associated with gastroduodenal ulcers, such as …

ContextConventional nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a
spectrum of toxic effects, notably gastrointestinal (GI) effects, because of inhibition of …

In a very short time, COX-2 enzyme inhibitors have gone from the darlings to the pariahs of
the pharmaceutical industry. These drugs were developed based on the hypothesis …