About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

The Sec machinery (or translocase) provides a major pathway of protein translocation from
the cytosol across the cytoplasmic membrane in bacteria. The SecA ATPase interacts …

Bacteria use several routes to target their exported proteins to the plasma membrane. The
majority are exported through pores formed by SecY and SecE. Two different molecular …

The major route of protein translocation in bacteria is the so-called general secretion
pathway (Sec-pathway). This route has been extensively studied in Escherichia coli and …

The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

Most bacterial secretory proteins pass across the cytoplasmic membrane via the
translocase, which consists of a protein-conducting channel SecYEG and an ATP …

More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

The vast majority of proteins trafficking across or into the bacterial cytoplasmic membrane
occur via the translocon. The translocon consists of the SecYEG complex that forms an …