Protein translocation across the bacterial cytoplasmic membrane

AJM Driessen, N Nouwen - Annu. Rev. Biochem., 2008 - annualreviews.org
About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

The Sec translocon mediated protein transport in prokaryotes and eukaryotes

K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Protein export through the bacterial Sec pathway

A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

The Sec protein-translocation pathway

H Mori, K Ito - Trends in microbiology, 2001 - cell.com
The Sec machinery (or translocase) provides a major pathway of protein translocation from
the cytosol across the cytoplasmic membrane in bacteria. The SecA ATPase interacts …

Protein traffic in bacteria: multiple routes from the ribosome to and across the membrane

M Müller, HG Koch, K Beck, U Schafer - 2000 - Elsevier
Bacteria use several routes to target their exported proteins to the plasma membrane. The
majority are exported through pores formed by SecY and SecE. Two different molecular …

The bacterial translocase: a dynamic protein channel complex

J De Keyzer, C Van Der Does… - Cellular and Molecular Life …, 2003 - Springer
The major route of protein translocation in bacteria is the so-called general secretion
pathway (Sec-pathway). This route has been extensively studied in Escherichia coli and …

Mechanisms of Sec61/SecY-mediated protein translocation across membranes

E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

The bacterial Sec-translocase: structure and mechanism

JA Lycklama a Nijeholt… - … Transactions of the …, 2012 - royalsocietypublishing.org
Most bacterial secretory proteins pass across the cytoplasmic membrane via the
translocase, which consists of a protein-conducting channel SecYEG and an ATP …

Breaking on through to the other side: protein export through the bacterial Sec system

KE Chatzi, MF Sardis, S Karamanou… - Biochemical …, 2013 - portlandpress.com
More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

[HTML][HTML] The sec translocase

DJF Du Plessis, N Nouwen, AJM Driessen - Biochimica et Biophysica Acta …, 2011 - Elsevier
The vast majority of proteins trafficking across or into the bacterial cytoplasmic membrane
occur via the translocon. The translocon consists of the SecYEG complex that forms an …