Novel genetic triggers and genotype–phenotype correlations in patients with left ventricular noncompaction

K Miszalski-Jamka, JL Jefferies, W Mazur… - Circulation …, 2017 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) is a genetically and phenotypically
heterogeneous disease and, although increasingly recognized in clinical practice, there is a …

Targeted panel sequencing in adult patients with left ventricular non‐compaction reveals a large genetic heterogeneity

P Richard, F Ader, M Roux, E Donal, JC Eicher… - Clinical …, 2019 - Wiley Online Library
Left ventricular non‐compaction (LVNC) is a cardiomyopathy that may be of genetic origin;
however, few data are available about the yield of mutation, the spectrum of genes and …

Genetic basis of left ventricular noncompaction

P Rojanasopondist, L Nesheiwat… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Left ventricular noncompaction (LVNC) is the third most common pediatric
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …

[HTML][HTML] Genetic architecture of left ventricular noncompaction in adults

SB Ross, ES Singer, E Driscoll, N Nowak… - Human genome …, 2020 - nature.com
The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …

A wide and specific spectrum of genetic variants and genotype–phenotype correlations revealed by next‐generation sequencing in patients with left ventricular …

C Wang, Y Hata, K Hirono, A Takasaki… - Journal of the …, 2017 - Am Heart Assoc
Background Left ventricular noncompaction (LVNC) has since been classified as a primary
genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present …

The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy

YM Hoedemaekers, K Caliskan, M Michels… - Circulation …, 2010 - Am Heart Assoc
Background—Left ventricular (LV) noncompaction (LVNC) is a distinct cardiomyopathy
featuring a thickened bilayered LV wall consisting of a thick endocardial layer with …

[HTML][HTML] Systematic large-scale assessment of the genetic architecture of left ventricular noncompaction reveals diverse etiologies

F Mazzarotto, MH Hawley, M Beltrami, L Beekman… - Genetics in …, 2021 - Elsevier
Purpose To characterize the genetic architecture of left ventricular noncompaction (LVNC)
and investigate the extent to which it may represent a distinct pathology or a secondary …

Novel gene locus for autosomal dominant left ventricular noncompaction maps to chromosome 11p15

S Sasse-Klaassen, S Probst, B Gerull, E Oechslin… - Circulation, 2004 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) is a congenital unclassified
cardiomyopathy with numerous prominent trabeculations and deep intertrabecular recesses …

Genetic analysis in patients with left ventricular noncompaction and evidence for genetic heterogeneity

Y Xing, F Ichida, T Matsuoka, T Isobe, Y Ikemoto… - Molecular genetics and …, 2006 - Elsevier
Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by numerous
excessively trabeculations and deep intertrabecular recesses. This study was performed to …

[HTML][HTML] Left ventricular noncompaction− Risk stratification and genetic consideration−

F Ichida - Journal of Cardiology, 2020 - Elsevier
Left ventricular noncompaction (LVNC) is a cardiomyopathy characterized by two layered
structures composed of prominent trabecular meshwork and deep intertrabecular recesses …