Barriers to participation in clinical trials of cancer: a meta-analysis and systematic review of patient-reported factors

EJ Mills, D Seely, B Rachlis, L Griffith, P Wu… - The lancet …, 2006 - thelancet.com
Background Enrolling participants onto clinical trials of cancer presents an important
challenge. We aimed to identify the concerns of patients with cancer about, and the barriers …

“When offered to participate”: a systematic review and meta-analysis of patient agreement to participate in cancer clinical trials

JM Unger, DL Hershman, C Till… - JNCI: Journal of the …, 2021 - academic.oup.com
Background Patient participation in clinical trials is vital for knowledge advancement and
outcomes improvement. Few adult cancer patients participate in trials. Although patient …

Attitudes towards and participation in randomised clinical trials in oncology: a review of the literature

PM Ellis - Annals of Oncology, 2000 - Elsevier
Background Clinical trials are the principal means by which new treatment approaches are
evaluated in medicine. It has been argued that randomised clinical trials provide the highest …

A systematic review highlights threats to validity in studies of barriers to cancer trial participation

D Fayter, C McDaid, A Eastwood - Journal of clinical epidemiology, 2007 - Elsevier
OBJECTIVE: To investigate the barriers, modifiers, and benefits involved in participating in
randomized controlled trials of cancer therapies as perceived by health care providers and …

Patients' willingness to participate in clinical trials and their views on aspects of cancer research: results of a prospective patient survey

SY Moorcraft, C Marriott, C Peckitt, D Cunningham… - Trials, 2016 - Springer
Background Recruitment to clinical trials can be challenging and slower than anticipated.
This prospective patient survey aimed to investigate the proportion of patients approached …

[HTML][HTML] Barriers to participation in clinical trials: a physician survey

A Mahmud, O Zalay, A Springer, K Arts… - Current …, 2018 - pmc.ncbi.nlm.nih.gov
Background Clinical trials are vital for evidence-based cancer care. Oncologist engagement
in clinical trials has an effect on patient recruitment, which in turn can affect trial success …

[HTML][HTML] Factors affecting patient participation in clinical trials in Ireland: a narrative review

E Walsh, A Sheridan - Contemporary Clinical Trials Communications, 2016 - Elsevier
Objective Clinical trials have long been considered the 'gold standard'of research generated
evidence in health care. Patient recruitment is an important determinant in the success of the …

Why patients don't take part in cancer clinical trials: an overview of the literature

K Cox, J McGarry - European journal of cancer care, 2003 - Wiley Online Library
Why patients don't take part in cancer clinical trials: an overview of the literature Clinical
trials have been recognized extensively within the literature as a crucial component in the …

Systematic review and meta-analysis of the magnitude of structural, clinical, and physician and patient barriers to cancer clinical trial participation

JM Unger, R Vaidya, DL Hershman… - JNCI: Journal of the …, 2019 - academic.oup.com
Background Barriers to cancer clinical trial participation have been the subject of frequent
study, but the rate of trial participation has not changed substantially over time. Studies often …

Hope for a cure and altruism are the main motives behind participation in phase 3 clinical cancer trials

T Godskesen, MG Hansson, P Nygren… - European journal of …, 2015 - Wiley Online Library
It is necessary to carry out randomised clinical cancer trials (RCT s) in order to evaluate new,
potentially useful treatments for future cancer patients. Participation in clinical trials plays an …