An approximate model of polygenic inheritance
K Lange - Genetics, 1997 - academic.oup.com
The finite polygenic model approximates polygenic inheritance by postulating that a
quantitative trait is determined by n independent, additive loci. The 3 n possible genotypes …
quantitative trait is determined by n independent, additive loci. The 3 n possible genotypes …
The finite polygenic mixed model: an alternative formulation for the mixed model of inheritance
RL Fernando, C Stricker, RC Elston - Theoretical and Applied Genetics, 1994 - Springer
This paper presents a mixed model of inheritance with a finite number of polygenic loci. This
model leads to a likelihood that can be calculated using efficient algorithms developed for …
model leads to a likelihood that can be calculated using efficient algorithms developed for …
Variance components/major locus likelihood approximation for quantitative, polychotomous, and multivariate data
SJ Hasstedt - Genetic epidemiology, 1993 - Wiley Online Library
Abstract Pearson [Philos Trans R Soc Lond [A] 200: 1–66, 1903], Mendell and Elston
[Biometrics 30: 41–57, 1974], and Rice et al.[Biometrics 35: 451–459, 1979] approximated …
[Biometrics 30: 41–57, 1974], and Rice et al.[Biometrics 35: 451–459, 1979] approximated …
Linkage analysis with an alternative formulation for the mixed model of inheritance: the finite polygenic mixed model.
C Stricker, RL Fernando, RC Elston - Genetics, 1995 - academic.oup.com
This paper presents an extension of the finite polygenic mixed model of Fernando et
al.(1994) to linkage analysis. The finite polygenic mixed model, extended for linkage …
al.(1994) to linkage analysis. The finite polygenic mixed model, extended for linkage …
Quantitative genetic models for describing simultaneous and recursive relationships between phenotypes
D Gianola, D Sorensen - Genetics, 2004 - academic.oup.com
Multivariate models are of great importance in theoretical and applied quantitative genetics.
We extend quantitative genetic theory to accommodate situations in which there is linear …
We extend quantitative genetic theory to accommodate situations in which there is linear …
Ascertainment and goodness of fit of variance component models for pedigree data.
The multivariate normal parameterization of the polygenic model (Lange et al., 1976)
provides a great deal of flexibility for analyzing quantitative data on pedigrees. The …
provides a great deal of flexibility for analyzing quantitative data on pedigrees. The …
Estimation of additive and dominance variance components in finite polygenic models and complex pedigrees
FX Du, I Hoeschele, KM Gage-Lahti - Genetics Research, 1999 - cambridge.org
Estimation of variance components with the finite polygenic model (FPM) was evaluated.
Phenotypic data for a 6300-pedigree simulated under a wide range of additive genetic …
Phenotypic data for a 6300-pedigree simulated under a wide range of additive genetic …
Estimation of genetic model parameters: variables correlated with a quantitative phenotype exhibiting major locus inheritance
SJ Hasstedt, PP Moll, DC Rao - Genetic epidemiology, 1989 - Wiley Online Library
A major locus that is detected through its effect on one phenotype (a primary trait) may also
affect other quantitative phenotypes or qualitative disease endpoints (secondary traits). The …
affect other quantitative phenotypes or qualitative disease endpoints (secondary traits). The …
How to model a complex trait: 1. General considerations and suggestions
K Strauch, R Fimmers, MP Baur, TF Wienker - Human heredity, 2003 - karger.com
Usually, when complex traits are at issue, not only are the loci of the responsible genes a
priori unknown; the same also holds for the mode of inheritance of the trait, and sometimes …
priori unknown; the same also holds for the mode of inheritance of the trait, and sometimes …
Quantitative genetic methods depending on the nature of the phenotypic trait
P de Villemereuil - Annals of the New York Academy of …, 2018 - Wiley Online Library
A consequence of the assumptions of the infinitesimal model, one of the most important
theoretical foundations of quantitative genetics, is that phenotypic traits are predicted to be …
theoretical foundations of quantitative genetics, is that phenotypic traits are predicted to be …