The finite polygenic model approximates polygenic inheritance by postulating that a
quantitative trait is determined by n independent, additive loci. The 3 n possible genotypes …

This paper presents a mixed model of inheritance with a finite number of polygenic loci. This
model leads to a likelihood that can be calculated using efficient algorithms developed for …

Abstract Pearson [Philos Trans R Soc Lond [A] 200: 1–66, 1903], Mendell and Elston
[Biometrics 30: 41–57, 1974], and Rice et al.[Biometrics 35: 451–459, 1979] approximated …

This paper presents an extension of the finite polygenic mixed model of Fernando et
al.(1994) to linkage analysis. The finite polygenic mixed model, extended for linkage …

Multivariate models are of great importance in theoretical and applied quantitative genetics.
We extend quantitative genetic theory to accommodate situations in which there is linear …

The multivariate normal parameterization of the polygenic model (Lange et al., 1976)
provides a great deal of flexibility for analyzing quantitative data on pedigrees. The …

Estimation of variance components with the finite polygenic model (FPM) was evaluated.
Phenotypic data for a 6300-pedigree simulated under a wide range of additive genetic …

A major locus that is detected through its effect on one phenotype (a primary trait) may also
affect other quantitative phenotypes or qualitative disease endpoints (secondary traits). The …

Usually, when complex traits are at issue, not only are the loci of the responsible genes a
priori unknown; the same also holds for the mode of inheritance of the trait, and sometimes …

A consequence of the assumptions of the infinitesimal model, one of the most important
theoretical foundations of quantitative genetics, is that phenotypic traits are predicted to be …