Complementing cancer photodynamic therapy with ferroptosis through iron oxide loaded porphyrin-grafted lipid nanoparticles

X Liang, M Chen, P Bhattarai, S Hameed, Y Tang… - ACS …, 2021 - ACS Publications
Nanomaterials that combine multimodality imaging and therapeutic functions within a single
nanoplatform have drawn extensive attention for molecular medicines and biological …

Iron-based nanoparticles for MR imaging-guided ferroptosis in combination with photodynamic therapy to enhance cancer treatment

Q Chen, X Ma, L Xie, W Chen, Z Xu, E Song, X Zhu… - Nanoscale, 2021 - pubs.rsc.org
Ferroptosis therapy, which applies ferroptotic inducers to produce lethal lipid peroxidation
and induce the death of tumor cells, is regarded as a promising therapeutic strategy for …

Cell membrane camouflaged Metal Oxide–Black Phosphorus Biomimetic Nanocomplex enhances photo-chemo-dynamic ferroptosis

K Chen, H Li, A Zhou, X Zhou, Y Xu… - ACS Applied Materials …, 2022 - ACS Publications
Despite the availability of various treatment options, the inherent complexity of tumors
significantly impairs therapeutic efficacy. Recently, combination treatments exhibited great …

pH-activated nanoplatform for visualized photodynamic and ferroptosis synergistic therapy of tumors

R Sun, W Ma, M Ling, C Tang, M Zhong, J Dai… - Journal of Controlled …, 2022 - Elsevier
To overcome drug resistance and improve precision theranostics for hepatocellular
carcinoma (HCC), a nanoplatform with an “off/on” function for multimodality imaging (near …

Biomimetic photosensitizer nanocrystals trigger enhanced ferroptosis for improving cancer treatment

M Wu, W Ling, J Wei, R Liao, H Sun, D Li… - Journal of Controlled …, 2022 - Elsevier
As a novel non-apoptotic cell death pathway, ferroptosis can effectively enhance the
antitumor effects of photodynamic therapy (PDT) by disrupting intracellular redox …

[HTML][HTML] Ferroptosis promotes photodynamic therapy: supramolecular photosensitizer-inducer nanodrug for enhanced cancer treatment

T Zhu, L Shi, C Yu, Y Dong, F Qiu, L Shen, Q Qian… - Theranostics, 2019 - ncbi.nlm.nih.gov
The noninvasive nature of photodynamic therapy (PDT) enables the preservation of organ
function in cancer patients. However, PDT is impeded by hypoxia in the tumor …

Oxygen-boosted biomimetic nanoplatform for synergetic phototherapy/ferroptosis activation and reversal of immune-suppressed tumor microenvironment

Z He, H Zhou, Y Zhang, X Du, S Liu, J Ji, X Yang… - Biomaterials, 2022 - Elsevier
Photodynamic therapy (PDT) induces apoptosis of cancer cells by generating cytotoxic
reactive oxygen species, the therapeutic effect of which, however, is impeded by …

Fenton reaction-assisted photodynamic therapy for cancer with multifunctional magnetic nanoparticles

H Hou, X Huang, G Wei, F Xu, Y Wang… - ACS applied materials …, 2019 - ACS Publications
Tumor hypoxia and the short half-life of reactive oxygen species (ROS) with small diffusion
distance have greatly limited the therapeutic effect of photodynamic therapy (PDT). Here, a …

Hypoxia-responsive nanoreactors based on self-enhanced photodynamic sensitization and triggered ferroptosis for cancer synergistic therapy

X Wang, M Wu, X Zhang, F Li, Y Zeng, X Lin… - Journal of …, 2021 - Springer
Background Photodynamic therapy (PDT), a typical reactive oxygen species (ROS)-
dependent treatment with high controllability, has emerged as an alternative cancer therapy …

Lipid droplet targeting type I photosensitizer for ferroptosis via lipid peroxidation accumulation

T Xiong, Y Chen, Q Peng, S Lu, S Long, M Li… - Advanced …, 2024 - Wiley Online Library
As an iron‐dependent lipid peroxidation (LPO) mediated cell death pathway, ferroptosis
offers promises for anti‐tumor treatment. Photodynamic therapy (PDT) is an ideal way to …