Background and purpose: Thoracic aortic dissection is a life‐threatening complication of
Marfan syndrome, a connective tissue disorder caused by mutations in the gene encoding …

Background The effect of FBN1 mutation type on the severity of cardiovascular
manifestations in patients with Marfan syndrome (MFS) has been reported with disparity …

Background Marfan syndrome (MFS) is a disorder of autosomal dominant inheritance, in
which aortic root dilation is the main cause of morbidity and mortality. Fibrillin-1 (FBN-1) …

Marfan syndrome (MFS) is a life-threatening autosomal dominant condition with a
prevalence ranging from one every 3000 to one every 5000 persons. 1 Aortic root dissection …

Marfan syndrome (MFS) is a systemic connective tissue disorder caused by mutations in the
fibrillin‐1 (FBN1) gene, and cardiovascular involvement is the leading cause of mortality. We …

Background. The leading cause of mortality in patients with Marfan syndrome (MFS) is
thoracic aortic aneurysm and dissection. Notch signaling is essential for vessel …

Abstract The fibrillin-1 (FBN1) gene mutations result in Marfan syndrome (MFS) and have a
variety of phenotypic variations. This disease is involved in the skeletal, ocular and …

Background Marfan syndrome (MFS) represents a genetic disorder with variable phenotypic
expression. The main cardiovascular sequelae of MFS include aortic aneurysm/dissection …

Marfan syndrome (MFS) is a pleiotropic inheritable connective tissue disorder with its main
manifestations in the ocular, skeletal, and cardiovascular organ systems. 1 Life expectancy …

Rationale: Aneurysm and dissection of the ascending thoracic aorta are the main
cardiovascular complications of Marfan syndrome (MFS) resulting in premature death …