Artificial thymidine monomers possessing amide or N-methylamide bridges were designed,
synthesized, and introduced into oligonucleotides. UV-melting experiments showed that …

2′, 4′-Bridged nucleic acid (2′, 4′-BNA) analogues are used for therapeutic
oligonucleotides, owing to their excellent hybridizing ability with complementary RNA and …

Oligonucleotides containing 4′-carboxy-, 4′-methoxycarbonyl-, 4′-carbamoyl-, and 4′-
methylcarbamoyl-thymidines, and their 2′-methoxy, 2′-amino or 2′-acetamido analogs …

Convenient chemical synthesis and incorporation of dithymidine and thymidine− cytidine
dimer blocks connected with a five-atom amide linker N3 '− CO− CH2− S− CH2 into …

Oligonucleotides containing 4′-C-aminomethyl-2′-O-methyl or 4′-C-aminomethyl-2′-
deoxy-2′-fluoro modified thymidines have been synthesized. Compared with the …

The synthesis of modified oligonucleotides is of great importance for various therapeutic and
diagnostic applications. The facile secondary structure formation of N-oxyamide-linked …

The synthesis of thymidine dimers 5a, b containing a chiral carbon in the propionamide
internucleosidic linkage is described. These new epimeric dimers were incorporated in …

Oligodeoxynucleotides containing the double-headed nucleoside 5′(S)-C-(2-(thymin-1-yl)
ethyl) thymidine were prepared by standard solid phase synthesis. The synthetic building …

4′-C-(Hydroxymethyl) thymidine derivative 1 was transformed into phosphoramidite 7
which was used for incorporation of 4′-C-hydroxymethyl functionalized thymidine …

A gapmer-type antisense oligonucleotide is an oligonucleotide therapeutic that targets
pathogenic mRNA directly, and it is expected to be a next-generation therapeutic drug. In …