As revealed by previous microdialysis studies, basal and food intake-accompanied
dopamine release significantly differs in the hypothalamus of obese vs. lean Zucker rats. In …

Brain dopaminergic pathways play a major role in the control of movement. Absence of the
murine dopamine D2 receptor gene (drd2) produces bradykinesia and hypothermia. A …

Chronic overeating of obesogenic diets can lead to obesity, reduced dopamine signaling,
and increased consumption of added sugars to compensate for blunted reward. However …

Over the last decade accumulating evidence suggests that brain dopamine (DA) has a role
in depression, particularly given the high comorbidity of depression with Parkinson's …

OBJECTIVE: The A1 allele of the TaqIA polymorphism in the dopamine D2 receptor gene
(rs1800497) has been associated with obesity. However, the effect of the polymorphism on …

The thrifty genotype hypothesis postulates that the genetically determined ability to grow
obese and insulin resistant in times of food abundance confers a survival advantage in times …

There is significant evidence linking a 'reward deficiency syndrome'(RDS), comprising
decreased availability of striatal dopamine D2-like receptors (DD2lR) and addiction-like …

The development of diet-induced obesity (DIO) can potently alter multiple aspects of
dopamine signaling, including dopamine transporter (DAT) expression and dopamine …

High impulsivity, mediated through ventral striatal dopamine signalling, represents an
established risk factor for substance abuse, and may likewise confer vulnerability to …

Stimulation or blockade of various dopamine receptor subtypes is associated with reduced
feeding. For example, D2 receptor agonists suppress feeding in food‐deprived and free …