Obesity has reached epidemic prevalence, and much research has focused on homeostatic
and nonhomeostatic mechanisms underlying overconsumption of food. Mesocorticolimbic …

Highlights•Obesity and addiction result in diminished D2 receptor availability in striatum.•D2
receptors control compulsive eating.•DREADDs and optogenetics have revealed a key role …

Objective The dopamine D2/3 receptor subtypes (DRD2/3) are the most widely studied
neurotransmitter biomarker in research on obesity, but results to date have been …

The reinforcing value of food, measured by how hard someone is willing to work to obtain
food, is influenced by food palatability, food deprivation and food variety, and may be a more …

Abstract Attention-Deficit/Hyperactivity Disorder (ADHD) and obesity are frequently
comorbid, genetically correlated, and share brain substrates. The biological mechanisms …

Obesity is a multifactorial disease caused by the interaction between genotype and
environment, and it is considered to be a type of addictive alteration. The A1 allele of the …

Because food intake exerts its rewarding effect by increasing dopamine (DA) signaling in
reward circuitry, it theoretically follows that individuals with a greater number of genotypes …

Although long-studied in the central nervous system, there is increasing evidence that
dopamine (DA) has important roles in the periphery including in metabolic regulation. Insulin …

Objective Interactions between pre‐existing differences in mesolimbic function and
neuroadaptations induced by consumption of fatty, sugary foods are thought to contribute to …

The aim of this study was to assess the anti-obesity effects of nucleus accumbens shell (NAc-
sh) deep brain stimulation (DBS) in diet-induced obese (DIO) and chow-fed (chow) rats. The …