The complement system is part of the innate immune response responsible for removing
pathogens and cellular debris, in addition to helping to refine CNS neuronal connections via …

The decline of cognitive function has emerged as one of the greatest health threats of old
age. Age-related cognitive decline is caused by an impacted neuronal circuitry, yet the …

Injury and inflammation are potent regulators of adult neurogenesis. As the complement
system forms a key immune pathway that may also exert critical functions in neural …

Traumatic brain injury (TBI) is of particular concern for the aging community since there is
both increased incidence of TBI and decreased functional recovery in this population. In …

The complement cascade not only is an innate immune response that enables removal of
pathogens but also plays an important role in microglia-mediated synaptic refinement during …

Complement is involved in developmental synaptic pruning and pathological synapse loss
in Alzheimer's disease. It is posited that C1 binding initiates complement activation on …

While the mechanisms underlying the functions of the complement system in the central
nervous system (CNS) and systemically, namely opsonization, chemotaxis, membrane lysis …

Previous work implicated the complement system in adult neurogenesis as well as
elimination of synapses in the developing and injured CNS. In the present study, we used …

The complement cascade is an important arm of the immune system that plays a key role in
protecting the central nervous system (CNS) from infection. Recently, it has also become …

Recent discoveries implicate the classical complement cascade in normal brain
development and in disease. Complement proteins C1q, C3, and C4 participate in synapse …