Sleep and circadian rhythms in α‐synucleinopathies—perspectives for disease modification

D Kunz, H Oster, O Rawashdeh… - Acta …, 2023 - Wiley Online Library
The global north is facing an unprecedented rise in the prevalence of neurodegenerative
diseases. The increasing incidence of Parkinson's disease is being referred to as a …

REM behaviour disorder and neurodegenerative diseases

S Zanigni, G Calandra-Buonaura, D Grimaldi, P Cortelli - Sleep Medicine, 2011 - Elsevier
Rapid-eye movement (REM) sleep behaviour disorder (RBD) is an REM sleep parasomnia
characterized by enactment of dream content during REM sleep associated with loss of …

Rapid eye movement sleep behavior disorder and the link to alpha-synucleinopathies

DA Barone, C Henchcliffe - Clinical Neurophysiology, 2018 - Elsevier
Rapid eye movement (REM) sleep behavior disorder (RBD) involves REM sleep without
atonia in conjunction with a recurrent nocturnal dream enactment behavior, with …

Idiopathic REM sleep behaviour disorder and neurodegeneration—an update

B Högl, A Stefani, A Videnovic - Nature Reviews Neurology, 2018 - nature.com
So-called idiopathic rapid eye movement (REM) sleep behaviour disorder (RBD), formerly
seen as a rare parasomnia, is now recognized as the prodromal stage of an α …

[HTML][HTML] Rapid eye movement sleep behavior disorder and neurodegenerative diseases: an update

F Zhang, L Niu, X Liu, Y Liu, S Li, H Yu, W Le - Aging and disease, 2020 - ncbi.nlm.nih.gov
Rapid eye movement sleep behavior disorder (RBD) is a sleep behavior disorder
characterized by abnormal behaviors and loss of muscle atonia during rapid eye movement …

Sleep-controlling neurons are sensitive and vulnerable to multiple forms of α-synuclein: implications for the early appearance of sleeping disorders in α …

AB Dos Santos, LK Skaanning… - Cellular and Molecular …, 2022 - Springer
Abstract Parkinson's disease, Multiple System Atrophy, and Lewy Body Dementia are
incurable diseases called α-synucleinopathies as they are mechanistically linked to the …

Sleep disturbance as potential risk and progression factor for Parkinson's disease

NI Bohnen, M Hu - Journal of Parkinson's disease, 2019 - content.iospress.com
Sleep disturbances are common and a major source of disability in Parkinson's disease
(PD). Primary and secondary insomnia, rapid eye movement sleep behavior disorder (RDB) …

Pharmacological interventions targeting α-synuclein aggregation triggered REM sleep behavior disorder and early development of Parkinson's disease

L Du, X He, X Fan, X Wei, L Xu, T Liang, C Wang… - Pharmacology & …, 2023 - Elsevier
Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized
by elevated motor behaviors and dream enactments in REM sleep, often preceding the …

Circadian dysfunction in a mouse model of Parkinson's disease

T Kudo, DH Loh, D Truong, Y Wu, CS Colwell - Experimental neurology, 2011 - Elsevier
Many Parkinson's disease (PD) patients exhibit sleep disorders as part of their symptoms
with evidence suggesting that REM sleep disorders may be intimately associated with this …

Morbidities in rapid eye movement sleep behavior disorder

P Jennum, G Mayer, YE Ju, R Postuma - Sleep medicine, 2013 - Elsevier
Idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD, RBD without any
obvious comorbid major neurological disease), is strongly associated with numerous …