We previously identified a common set of genes, termed atrogenes, whose expression is
coordinately induced or suppressed in muscle during systemic wasting states (fasting …

The molecular mechanisms underlying skeletal muscle maintenance involve interplay
between multiple signaling pathways. Under normal physiological conditions, a network of …

Sarcopenia, the progressive loss of muscle mass with age, is characterized by a
deterioration of muscle quantity and quality leading to a gradual slowing of movement and a …

The aim of the present review is to summarise, evaluate and critique the different
mechanisms involved in anabolic growth of skeletal muscle and the catabolic processes …

Atrophy occurs in specific muscles with inactivity (for example, during plaster cast
immobilization) or denervation (for example, in patients with spinal cord injuries). Muscle …

Gain or loss of skeletal muscle mass occurs in situations of altered use such as strength
training, aging, denervation, or immobilization. This review examines our current …

Skeletal muscles, especially weight-bearing muscles, are very sensitive to changes in
loading state. The aim of this paper was to characterize the dynamic changes in the …

Numerous health problems including acute critical illness, cancer, diseases associated with
chronic inflammation, and neurological disorders often result in skeletal muscle weakness …

Periods of immobilisation are often associated with pathologies and/or ageing. These
periods of muscle disuse induce muscle atrophy which could worsen the pathology or …

Physical inactivity (PI) is a major risk factor of chronic diseases. A major aspect of PI is loss
of muscle mass and strength. The latter phenomenon significantly impacts daily life and …