Activation of G protein-gated K÷ channels by G protein-coupled receptors contributes to
parasympathetic regulation of heart rate in the atrium and inhibitory postsynaptic potentials …

In neuronal and atrial tissue, G protein-gated inwardly rectifying K+ channels (Kir3. x family)
are responsible for mediating inhibitory postsynaptic potentials and slowing the heart rate …

Guanine nucleotide-binding proteins (G proteins) activate K+ conductances in cardiac atrial
cells to slow heart rate and in neurons to decrease excitability. cDNAs encoding three …

We have previously shown that direct binding of the βγ subunit of G protein (Gβγ) to both the
N-terminal domain and the C-terminal domain of a cloned G protein-gated inward-rectifying …

Activation of heterotrimeric GTP-binding (G) proteins by their coupled receptors, causes
dissociation of the G protein α and βγ subunits. G βγ subunits interact directly with G protein …

Abstract G protein-gated K+(GIRK, or Kir3) channels mediate inhibitory neurotransmission
via G protein-coupled receptors (GPCRs) in heart and brain. The signaling cascade involves …

G protein-gated inward rectifier K+ (GIRK) channels mediate hyperpolarizing postsynaptic
potentials in the nervous system and in the heart during activation of Gα (i/o)-coupled …

In many tissues, inwardly rectifying K channels are coupled to seven-helix receptors via the
Gi/Go family of heterotrimeric G proteins. This activation proceeds at least partially via G beta …

G protein-activated K+ channels (GIRKs; Kir3) are activated by direct binding of Gβγ
subunits released from heterotrimeric G proteins. In native tissues, only pertussis toxin …

G protein-activated K+ channels (Kir3 or GIRK) are activated by direct binding of Gβγ. The
binding sites of Gβγ in the ubiquitous GIRK1 (Kir3. 1) subunit have not been unequivocally …