Abstract Background The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised
(ALSFRS-R) is the preferred measure of health outcome in clinical trials in motor neuron …

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease typically causing death
within three years. Understanding the impact of disease on patients using health utility at …

Aims To estimate the health utilities and quality-adjusted life years (QALYs) in patients with
amyotrophic lateral sclerosis (ALS) receiving reldesemtiv versus placebo in FORTITUDE …

Objective The objectives of this study were to 1) assess the content validity of generic
preference-based measures (GPBMs), and (2) examine the convergent validity of the …

Objectives This study assessed the feasibility of using the Milano-Torino staging (MiToS)
system for conducting economic evaluation to measure health outcomes in amyotrophic …

Abstract Background The Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised
(ALSFRS-R) total score is a widely used measure of functional status in Amyotrophic Lateral …

Background Selection of appropriate trial endpoints and outcome measures is particularly
important in rare disease and rapidly progressing disease such as amyotrophic lateral …

We appreciate the interest in our efforts to calculate a minimal important difference (MID) for
the revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R)(1) and are …

Abstract Objectives The 29-item Multiple Sclerosis Impact Scale (MSIS-29) is a
psychometrically validated patient-reported outcome measure increasingly used in trials of …

The ALS Functional Rating Scale-Revised (ALSFRS-R) is used in the clinic to chart
progression and as a primary endpoint measure in clinical trials. In the original description of …