The lungs are directly exposed to higher oxygen concentrations than most other tissues.
Increased oxidative stress is a significant part of the pathogenesis of obstructive lung …

Studies have implicated active oxygen species (AOS) in the pathogenesis of various lung
diseases. Many chemical and physical agents in the environment are potent generators of …

To test the hypothesis that increases in lung superoxide dismutase can cause tolerance to
pulmonary oxygen toxicity, we studied transgenic mice which constitutively express elevated …

Reactive oxygen species, such as superoxide radicals, are thought to underlie the
pathogenesis of various diseases. Almost 3 to 10% of the oxygen utilized by tissues is …

Abstract Superoxide (O2-) has been implicated in the pathogenesis of pulmonary O2 toxicity.
The studies using transgenic and knockout mice of each of the three isoforms of superoxide …

In many pathological situations, tissue damage is caused by cellular generation of
superoxide free radicals (O2-). These active species are generated during post-ischemic …

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Tobacco smoke is the number one risk factor for chronic obstructive pulmonary disease
(COPD) and contains a high concentration of oxidants. The lung has a high concentration of …

Superoxide dismutases (SODs) are necessary antioxidant enzymes that protect cells from
reactive oxygen species (ROS). Decreased levels of SODs or mutations that affect their …

To test directly whether mitochondrial Mn-superoxide dismutase (Mn-SOD) protects the lung
epithelium from oxygen-induced injury, transgenic mice were produced in which the …