A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients
M Kanai, Y Otsuka, K Otsuka, M Sato… - Cancer chemotherapy …, 2013 - Springer
Background A growing number of preclinical studies have demonstrated that curcumin could
be a promising anticancer drug; however, poor bioavailability has been the major obstacle …
be a promising anticancer drug; however, poor bioavailability has been the major obstacle …
Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers
M Kanai, A Imaizumi, Y Otsuka, H Sasaki… - Cancer chemotherapy …, 2012 - Springer
Background More and more preclinical studies support the idea that curcumin, a plant-
derived natural polyphenol, could be a promising anticancer drug. However, poor …
derived natural polyphenol, could be a promising anticancer drug. However, poor …
[HTML][HTML] Exploring the contribution of curcumin to cancer therapy: A systematic review of randomized controlled trials
C De Waure, C Bertola, G Baccarini, M Chiavarini… - Pharmaceutics, 2023 - mdpi.com
Although the anticancer role of curcumin has been extensively addressed in preclinical
research, only a few studies were carried out in humans, with conflicting results. The aim of …
research, only a few studies were carried out in humans, with conflicting results. The aim of …
Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions
J Adiwidjaja, AJ McLachlan… - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Curcumin has been extensively studied for its anti-cancer properties. While a
diverse array of in vitro and preclinical research support the prospect of curcumin use as an …
diverse array of in vitro and preclinical research support the prospect of curcumin use as an …
[PDF][PDF] The dark side of curcumin
E Burgos‐Morón, JM Calderón‐Montaño… - International journal of …, 2010 - Citeseer
Dear Editor, Curcumin is a yellow–orange pigment obtained from the plant Curcuma longa.
The powdered rhizome of this plant, called turmeric, is a common ingredient in curry …
The powdered rhizome of this plant, called turmeric, is a common ingredient in curry …
[HTML][HTML] Therapeutic applications of curcumin for patients with pancreatic cancer
M Kanai - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
A number of preclinical studies have demonstrated anticancer effects for curcumin in various
types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone …
types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone …
[HTML][HTML] Clinical effects of curcumin in enhancing cancer therapy: A systematic review
K Mansouri, S Rasoulpoor, A Daneshkhah, S Abolfathi… - BMC cancer, 2020 - Springer
Background Curcumin is herbal compound that has been shown to have anti-cancer effects
in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the …
in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the …
[HTML][HTML] The golden spice curcumin in cancer: A perspective on finalized clinical trials during the last 10 years
Curcumin, the key bioactive phytochemical present in turmeric (Curcuma longa L.), is the
most studied natural compound in cancer. Preclinical studies (in vitro and in vitro) and …
most studied natural compound in cancer. Preclinical studies (in vitro and in vitro) and …
Pharmacokinetics of curcumin diethyl disuccinate, a prodrug of curcumin, in wistar rats
K Bangphumi, C Kittiviriyakul, P Towiwat… - European journal of …, 2016 - Springer
Abstract Background and Objectives Curcumin is the major bioactive component of turmeric,
but has poor oral bioavailability that limits its clinical applications. To improve the in vitro …
but has poor oral bioavailability that limits its clinical applications. To improve the in vitro …
Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications
G Bar-Sela, R Epelbaum… - Current medicinal …, 2010 - ingentaconnect.com
Curcumin, commonly called diferuloyl methane, is a hydrophobic polyphenol derived from
rhizome (turmeric) of the herb Curcuma longa. Extensive research over the last half century …
rhizome (turmeric) of the herb Curcuma longa. Extensive research over the last half century …