A phase I study investigating the safety and pharmacokinetics of highly bioavailable curcumin (Theracurmin®) in cancer patients

M Kanai, Y Otsuka, K Otsuka, M Sato… - Cancer chemotherapy …, 2013 - Springer
Background A growing number of preclinical studies have demonstrated that curcumin could
be a promising anticancer drug; however, poor bioavailability has been the major obstacle …

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

M Kanai, A Imaizumi, Y Otsuka, H Sasaki… - Cancer chemotherapy …, 2012 - Springer
Background More and more preclinical studies support the idea that curcumin, a plant-
derived natural polyphenol, could be a promising anticancer drug. However, poor …

[HTML][HTML] Exploring the contribution of curcumin to cancer therapy: A systematic review of randomized controlled trials

C De Waure, C Bertola, G Baccarini, M Chiavarini… - Pharmaceutics, 2023 - mdpi.com
Although the anticancer role of curcumin has been extensively addressed in preclinical
research, only a few studies were carried out in humans, with conflicting results. The aim of …

Curcumin as a clinically-promising anti-cancer agent: pharmacokinetics and drug interactions

J Adiwidjaja, AJ McLachlan… - Expert opinion on drug …, 2017 - Taylor & Francis
Introduction: Curcumin has been extensively studied for its anti-cancer properties. While a
diverse array of in vitro and preclinical research support the prospect of curcumin use as an …

[PDF][PDF] The dark side of curcumin

E Burgos‐Morón, JM Calderón‐Montaño… - International journal of …, 2010 - Citeseer
Dear Editor, Curcumin is a yellow–orange pigment obtained from the plant Curcuma longa.
The powdered rhizome of this plant, called turmeric, is a common ingredient in curry …

[HTML][HTML] Therapeutic applications of curcumin for patients with pancreatic cancer

M Kanai - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
A number of preclinical studies have demonstrated anticancer effects for curcumin in various
types of tumors, including pancreatic cancer. Curcumin has anticancer effects both alone …

[HTML][HTML] Clinical effects of curcumin in enhancing cancer therapy: A systematic review

K Mansouri, S Rasoulpoor, A Daneshkhah, S Abolfathi… - BMC cancer, 2020 - Springer
Background Curcumin is herbal compound that has been shown to have anti-cancer effects
in pre-clinical and clinical studies. The anti-cancer effects of curcumin include inhibiting the …

[HTML][HTML] The golden spice curcumin in cancer: A perspective on finalized clinical trials during the last 10 years

AKK Arslan, E Uzunhisarcıklı, MB Yerer… - Journal of Cancer …, 2022 - journals.lww.com
Curcumin, the key bioactive phytochemical present in turmeric (Curcuma longa L.), is the
most studied natural compound in cancer. Preclinical studies (in vitro and in vitro) and …

Pharmacokinetics of curcumin diethyl disuccinate, a prodrug of curcumin, in wistar rats

K Bangphumi, C Kittiviriyakul, P Towiwat… - European journal of …, 2016 - Springer
Abstract Background and Objectives Curcumin is the major bioactive component of turmeric,
but has poor oral bioavailability that limits its clinical applications. To improve the in vitro …

Curcumin as an anti-cancer agent: review of the gap between basic and clinical applications

G Bar-Sela, R Epelbaum… - Current medicinal …, 2010 - ingentaconnect.com
Curcumin, commonly called diferuloyl methane, is a hydrophobic polyphenol derived from
rhizome (turmeric) of the herb Curcuma longa. Extensive research over the last half century …